王焱

王焱教授

Ph.D. M.D.博导

厦门大学附属心血管病医院     院长

厦门大学心血管病研究所 主任

厦门市心血管疾病重点实验室 主任

邮箱:wy@medmail.com.cn  


教育背景

1985-1990    西安医科大学         临 床 医 学       本科

1993-1996    新疆医科大学        心血管内科       硕士

1999-2004    香港大学医学院    心血管内科       博士


工作经历

1990-1996    新疆医科大学附属第一医院    心内科    住院医师、主治医师

1996-2001    香港玛丽医院       心内科    注册医师

2002-2003    香港圣保禄医院   心内科    注册医师          

2001-2014    厦门大学附属中山医院    心内科     主任医师

2015-2016    厦门市心血管病医院(厦门市心脏中心)  院长

2016-至今    厦门大学附属心血管病医院(厦门市心脏中心) 院长


主要研究领域

王焱教授长期从事心血管转化医学研究,主要兴趣在心脏介入临床研究、动脉粥样硬化机制与临床研究、缺血再灌注损伤与心肌保护研究、心脏干细胞研究、离子通道与心律失常发病机制研究,中药有效成分对心血管疾病治疗作用研究等;近年来以第一/通讯作者在国际知名杂志发表论著20余篇;承担国家自然科学基金重点项目、国家科技部重点研发项目等国家、省、市级科研项目10余项,科研经费超过2000万元。


主要论著(自2013年)

1. Du, Qian., Qian, Ming-Ming., Liu, Pin-Li., Zhang, Le.Wang Y. Liu, Dong-Hui, .  Glycation of high-density lipoprotein triggers oxidative stress and promotes the proliferation and migration of vascular smooth muscle cells. J Geriatr Cardiol. 2017;14(7), 473-480 [Abstract] 

2. Liu, Donghui., Ding, Zhenzhen., Wu, Mengzhang., Xu, Wenqi., Qian, Mingming., Du, Qian.  Wang Yan#. the apolipoprotein A-I mimetic peptide, D-4F, alleviates ox-LDL-induced oxidative stress and promotes endothelial repair through the eNOS/HO-1 pathway .  J. Mol. Cell. Cardiol.l. 2017; 105, 77-88  [Abstract] IF=5.67

3. Deng, Xiu-Ling., Wang, Yan., Xiao, Guo-Sheng. Effects of equol on multiple K+ channels stably expressed in HEK 293 cells.  PLoS ONE. 2017;12(8), e0183708.[Abstract] 

4. Li G, Wang Y#,,Li GR..Bradykinin regulates cell growth and migration in cultured human cardiac c-Kit+ progenitor cells.  Oncotarget.. 2017 Feb 14;8(7):10822-10835.[Abstract]  IF=5.167

5. Xiao GS, Zhang YH, Wu W, Sun HY, Wang Y, Li GR.Genistein and tyrphostin AG556 decrease human atrial ultra-rapidly activating delayed rectifier potassium current by inhibiting EGFR tyrosine kinase.  Br J Pharmacol.. 2017 Mar;174(6):454-467.[Abstract]  IF=IF=5.259

6. Jie LJ, Wu WY, Li G, Xiao GS, Zhang ST, Li GR,Wang Y#.Clemizole hydrochloride blocks cardiac potassium channels stably expressed in HEK293 cells.  Br J Pharmacol..  2017 Feb ;174(3).[Abstract]  IF=IF=5.259.

7. Wang Y, Wang Y#, Li GR. TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells. Oncotarget. 2016 Jul 26.[Full Text]  [Abstract]   IF=5.008

8.  Liu H, Yang L, Wu HJ, Chen KH, Lin F, Li G, Sun HY, Xiao GS, Wang Y, Li GR. Water-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury. Sci Rep. 2016; 6: 36435.  [Full Text]    [Abstract]   IF=5.228

9.  Liu H, Wang YJ, Yang L, Zhou M, Jin MW, Xiao GS, Wang Y, Sun HY, Li GR. Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs. Sci Rep. 2016; 6: 25743[Full Text]    [Abstract]  IF=5.228

10.  Che H, Xiao GS, Sun HY, Wang Y#, Li GR. Functional TRPV2 and TRPV4 channels in human cardiac c-Kit+ progenitor cells. J Cell Mol Med. 2016; 20: 1118-27.  [Abstract]   IF=4.938

11.  Liu H, Yang L, Chen KH, Sun HY, Jin MW, Xiao GS, Wang Y#, Li GR. SKF-96365 blocks human ether-à-go-go-related gene potassium channels stably expressed in HEK 293 cells. Pharmacol Res. 2016; 104: 61-69.   [Abstract]   IF=4.816

12.  Chen KH, Xu XH, Sun HY, Du XL, Liu , Yang L, Xiao GS .Wang Y, Jin MW, Li GR. Distinctive property and pharmacology of voltage-gated sodium current in rat atrial versus ventricular myocytes. Heart Rhythm. 2016; 13: 762-70.   [Abstract]   IF=4.319

13.  Cheng Y, Zhou M, Wang Y. Arctigenin antagonizes mineralocorticoid receptor to inhibit the transcription of Na/K-ATPase. J Recept Signal Transduct Res. 2016; 36: 181-8.   [Abstract]

14.  Che H, Li G, Sun HY, Xiao GS, Wang Y, Li GR. Roles of store-operated Ca2+ channels in regulating cell cycling and migration of human cardiac c-Kit+ progenitor cells. Am J Physiol Heart Circ Physiol. 2015; 30: H1772-81. [Abstract]   IF=3.324

15.  Wang B, Wang Y#. Acute coronary syndrome caused by left main coronary artery compression between the aortic root and massive dilation of the left atrium. Can J Cardiol. 2015; 31: 227.  [Abstract]   IF=3.112

16.  Zhang YY, Li G, Che H, Sun HY, Xiao GS, Wang Y#, Li GR. Effects of BKCa and Kir2.1 channels on cell cycling progression and migration in human cardiac c-Kit+ progenitor cells. PLoS One. 2015; 10: e0138581. [Abstract]   IF=3.057.

17.  Chen SL, Xu B, Han YL, Sheiban I, Zhang JJ, Ye F, Kwan TW, Paiboon C, Zhou YJ, Lv SZ, Dangas GD, Xu YW, Wen S, Hong L, Zhang RY, Wang HC, Jiang TM, Wang Y, Sansoto T, Chen F, Yuan ZY, Li WM, Leon MB. Clinical outcome after DK crush versus Culotte stenting of distal left main bifurcation lesions: the 3-year follow-up results of the DKCRUSH-III study. JACC Cardiovasc Interv. 2015; 8: 1335-42.  [Abstract]   IF=7.63

13.  Zhang YY, Li G, Che H, Sun HY, Li X, Au WK, Xiao GS, Wang Y#, Li GR. Characterization of functional ion channels in human cardiac c-Kit+ progenitor cells. Basic Res Cardiol. 2014; 109: 407.  [Abstract]   IF=6.038.

14.  Wang Y*, Ji L, Jiang R, Zheng L, Liu D. Oxidized high-density lipoprotein induces the proliferation and migration of vascular smooth muscle cells by promoting the production of ROS. J Atheroscler Thromb. 2014; 21: 204-16. [Abstract]  [Full text]   IF=2.459.

15.  Wang B, Wang Y#, Ye T, Xiao G, Chang H, Wen H, Chen Y, Lin J, Yang L, Ye J, Huang L, Chen L, Cui Y, Fan C, Wu Y, Zheng Q. Integrated regional network construction for ST-segment elevation myocardial infarction care. Zhong Hua Xin Xue Guan Bing Za Zhi. 2014; 42: 650-4.  [Abstract]

16.  Sun HY, Xiao GS, Wang Y, Li GR. Ionic mechanism underlying distinctive excitability in atrium and ventricle of the heart. Sheng Li Xue Bao. 2014 25; 66: 85-95.  [Abstract]

17.  Chen SL, Xu B, Han YL, Sheiban I, Zhang JJ, Ye F, Kwan TW, Paiboon C, Zhou YJ, Lv SZ, Dangas GD, Xu YW, Wen SY, Hong L, Zhang RY, Wang HC, Jiang TM, Wang Y, Chen F, Yuan ZY, Li WM, Leon MB. Comparison of double kissing crush versus Culotte stenting for unprotected distal left main bifurcation lesions: results from a multicenter, randomized, prospective DKCRUSH-III study. J Am Coll Cardiol. 2013; 61: 1482-8. [Abstract]   IF=17.759

18.  Chang H, Wang Y, Wu W, Li G, Hanawa H, Zou J . Hydrodynamics-based delivery of an interleukin-1 receptor II fusion gene ameliorates rat autoimmune myocarditis by inhibiting IL-1 and Th17 cell polarization. Int J Mol Med. 2013; 31: 833-40.  [Abstract]   IF=2.459.


承担课题

1. 国家自然科学基金重点项目: 心脏祖细胞在心肌梗死修复中的机制研究    2017.01-2020.01    主持

2. 科技部重点研发项目: 急性心肌梗死全程心肌保护体系研究   2016.09-2020.12    子课题负     责人

3. 厦门市科技局重大科技平台项目:冠心病急症的远程诊断和区域协同救治平台二期               2015.10-2018.09  主持

4. 厦门市重大疾病联合公关项目 : 经导管主动脉瓣植入在高危重度主动脉瓣狭窄合并左室     功能不全患者中的临床应用研究   2015.01-2017.12   主持

5. 福建省科技厅重点项目:经皮导管肾脏去神经法治疗顽固性高血压的临床技术研究                2014.01-2017.01  主持

6. 国家自然基金面上项目 : Kv1.3 通道在动脉粥样硬化中的作用研究    2009.01-2011.12              主持


获奖

1.厦门市医学创新奖经导管主动脉瓣植入术的临床应用及推广    2016.05

2. 厦门市科学技术重大贡献奖:全市覆盖区域协同胸痛急救网络     2015.12

3. 厦门市医学创新奖:区域协同ST段抬高型心肌梗死救治网络建设及临床应用  2015.02

4. 第九届中国医师奖   2014.06

5. 厦门市医学创新奖:冠脉内压力导丝技术在冠脉造影临界病变中的应用    2014.03