张杰

张杰   

国家优秀青年科学基金

教育部新世纪优秀人才

福建省杰出青年基金

福建省高等学校新世纪优秀人才;

厦门市五四青年奖章

厦门市重点人才                            

职称:教授/博导

学科(专业):神经生物学

研究方向:细胞周期调控与神经退行性疾病

邮箱:jiezhang@xmu.edu.cn

电话:0592-2180717



教育背景:

1997年9月-2001年7月, 四川大学,生命科学学院,学士

2001年9月-2006年7月, 中国科学院生物物理研究所,博士


工作经历:

2006年9月-2011年8月,美国新泽西州立大学,博士后-研究助理

2011年8月-至今, 厦门大学医学院,教授


主要研究领域:

张杰博士长期从事老年痴呆症(Alzheimer’s Disease, AD)的细胞与分子致病机理研究,主要从细胞周期紊乱调控和氧化应激的角度研究AD致病过程中神经元的凋亡机理。成熟神经元处于细胞周期静止期,生理状态下不会再分裂。而在AD中,大量神经元的细胞周期被重新激活,并最终诱导了神经元的凋亡。这是目前关于AD致病过程中发现最早的细胞功能紊乱。张杰教授课题组通过多年系统地工作研究发现:细胞周期蛋白激酶CDK5对于抑制AD中神经元细胞周期重新激活和延缓AD中神经元凋亡具有重要的作用。至今以第一作者或者通讯作者在国际知名期刊发表研究论文16篇。SCI他引500多次,H-index为15。其中回国独立开展研究工作以后,张杰教授作为通讯作者在PNAS(2014), The Journal of Neuroscience(2015), JBC(2012), Clinical Cancer Research(2015),Chemistry(2014),Chem. Biol. Drug Des. (2013)等杂志上发表多篇研究论文。以上研究成果被众多媒体所报道,同时受邀在多个国际会议上做学术报告。这些研究结果对于阐明AD的细胞与分子致病机制、发现AD 治疗靶标并开发新型治疗药物具有十分重要的意义。

实验室目前主要的研究方向为细胞周期调控与疾病发生。以神经推行性疾病、胃癌、肝癌等细胞周期进程中关键激酶为靶点,研究在疾病发生过程中细胞周期被重新激活的分子机制,并结合计算机模拟,小分子药物筛选等进行预防和治疗老年痴呆、恶性肿瘤等的药物开发研究。


主要学术成果:

代表性论文/著作/专利:

1

Jiechao Zhou, Huifang Li, Xiaoping Li, Guanyun Zhang, Yaqiong Niu, Zengqiang Yuan, Karl Herrup, YunWu Zhang, Guojun Bu, Huaxi Xu, Jie Zhang* Cdk5-mediated localization of FOXO1 regulates neuronal death. The Journal of Neuroscience 2015 Feb 11;35(6):2624-35(*Corresponding authors)

2

Hei-man Chow, Dong Guo, Jiechao Zhou, Guanyun Zhang, Huifang Li, Karl Herrup*, Zhang Jie*. CDK5 activator protein p25 preferentially binds and activates GSK3β. Proc Natl Acad Sci (USA). 2014 11, 111(45):E4887-95 (*Corresponding author)

3

Longlong Cao, Jiechao Zhou, Junrong Zhang, Sijin Wu, Xintao Yang, Xin Zhao, Huifang Li, Ming Luo, Qian Yu, Jianwei Xie, Ping Li, Xiaoqing Hu, Chaohui Zheng, Guojun Bu, Yun-wu Zhang, Huaxi Xu*, Yongliang Yang*, Changming Huang*, Jie Zhang*Cyclin dependent kinase 5 decreases in gastric cancer and its nuclear accumulation suppresses gastric tumorigenesis. Clinical Cancer Research (In press) *Co-corresponding authors

4

Mingshan Niu, Jin Hu, Sijin Wu, Xiaoe Zhang, Huaxi Xu, Yunwu Zhang, Jie Zhang*, Yongliang Yang * Structural Bioinformatics-Based Identification of EGFR Inhibitor Gefitinib as a Putative Lead Compound for BACE. Chem. Biol. Drug Des. 2014 Jan;83(1):81-88. (*Co-corresponding author)

5

Kang YF, Yan WJ, Zhou TW, Dai F, Li XZ, Bao XZ, Du YT, Yuan CH, Wang HB, Ren XR, Liu Q, Jin XL, Zhou B*, Zhang Jie*. Tailoring 3,3'-dihydroxyisorenieratene to hydroxystilbene: finding a resveratrol analogue with increased antiproliferation activity and cell selectivity. Chemistry. 2014 Jul 14; 20(29):8904-8. (*Co-corresponding author)

6

Zhang Jie*, Li Huifang, Zhou Tingwen, Zhou Jiechao, Herrup Karl*. Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase, J Biol. Chem. 287(31), 25985-94 (2012). (*corresponding authors)

7

Zhang Jie, Herrup K, Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons. Cell Cycle 10(8) 1208-14 (2011).

8

Zhang Jie, Huifang Li, Herrup Karl. Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex.The Journal of Neuroscience 30, 5219-5228 (2010).

9

Zhang Jie, Huifang Li, Herrup Karl. Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation, J. Biol. Chem. 285(18), 14052-61 (2010).

10

Zhang Jie, Cicero, S.A., Wang, L., Romito-Digiacomo, R.R., Yang, Y. and Herrup, K, Nuclear localization of Cdk5 is a key determinant in the post-mitotic state of neurons. Proc. Nat. Acad. Sci. (USA) 105, 8772-8777 (2008).

11

Zhang Jie, Herrup Karl. Cdk5 and the non-catalytic arrest of the neuronal cell cycle, Cell Cycle 7:3487-90 (2008)

12

Liu Qiang*, Zhang Jie*, Zhu Hua, Qin Chuan, Chen Qi and Zhao Baolu Zhao, Dissecting the signaling pathway of nicotine-mediated Nneuroprotection in amouse Alzheimer disease model. FASEB J. 21(1), 61-73(*Equal contribution) (2007)

13

Zhang Jie, Liu Qiang, Liu Nian-Qing, Li Fu-Liang, Chen Qi, Qin Chuan, Zhu  Hua, Huang Yu-Ying, He Wei, Zhao Bao-Lu, Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis. FASEB J. 20(8), 1212-4 (2006).

14

Zhang Jie, Mori Akitane, Chen Qi, Zhao Bao-Lu, Fermented papaya preparation attenuates beta-amyloid precursor protein: beta-amyloid-mediated copper neurotoxicity in beta-amyloid precursor protein and beta-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells. Neuroscience 143(1), 63-72 (2006).

15

Zhang Jie, Wang Xue-Fei, Lu Zhong-Bing, Liu Nian-Qing, Zhao Bao-Lu, The effects of meso-2, 3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus. Free Radic. Biol. Med. 37, 1037-1050 (2004).


近期CDK5信号通路研究总结: