任建林

任建林  “闽江学者”特聘教授


职称教授/博导

学科(专业):内科

研究方向:胃肠微生态及胃肠道肿瘤早诊早治

邮箱renjianl@xmu.edu.cn

电话:0592-2590151


教育背景:

1994-1997西安医科大学 内科学 硕士

2001-2004西安交通大学医学院 内科学 博士


工作经历:

1997.07-1999.12厦门大学附属中山医院 主治医师

1999.12-2005.07,厦门大学附属中山医院 副主任医师

2005.07-至今,厦门大学附属中山医院 主任医师

2006.06-至今,厦门大学附属中山医院 博士后导师

2008.05-至今,厦门大学医学院 教授



主要研究领域:

主要研究领域为胃肠微生态,胃肠道黏膜病变及胃肠道肿瘤早诊早治相关的基础与临床研究,涉及黏膜修复、炎症保护、肿瘤发生发展、分子诊断与靶向治疗等方面。主要包括微生态在消化道肿瘤中的作用与机制、粪菌移植的临床应用与技术研发、基于新型分子影像技术的内镜研发在消化道肿瘤早诊早治中的应用。



  

主要学术成果:

论文:

1

Shi Y#, Chen GB#, Huang QW#, Chen X, Liu JJ, Xu W, Liu YP, Xiao CX, Ren JL* (corresponding) and Guleng B*. miR218-5p regulates the proliferation of gastric cancer cells by targeting TFF1 in an Erk1/2-dependent manner. BBA - Molecular Basis of Disease. 2015, doi: 10.1016. (IF:5.089)

2

Liu JJ#, Wang X#, Yang XN, Liu YP, Shi Y, Ren JL*(corresponding) and Guleng B*. miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells. Cancer Lett. 347(1):98-104, 2014.(IF:5.016)

3

Wang HH#, Xie NN, Li QY, Hu YQ, Ren JL*(corresponding) and Guleng B*. Exome sequencing revealed novel germline mutations in Chinese Peutz-Jeghers syndrome patients. Dig Dis Sci. 59(1):64-71, 2014.

4

Xiao L#, Liu YP#, Xiao CX#, Ren JL*(corresponding)and Guleng B*. Serum TFF3 may be a pharamcodynamic marker of responses to chemotherapy in gastrointestinal cancers. BMC Clin Pathol. 2014, doi: 10.1186.

5

Yang XN#, Lu YP#, Liu JJ, Huang JK, Liu YP, Xiao CX, Jazag A, Ren JL*(corresponding) and Guleng B*. Piezo1 is as a novel trefoil factor family 1 binding protein that promotes gastric cancer cell mobility in vitro. Dig Dis Sci. 59(7):1428-35, 2014.

6

Li P#, Xiao L, Li YY, Chen X, Xiao CX, Liu JJ, Yang XN, Jazag A, Ren JL*(corresponding) and Guleng B*. Fibrinogen Alpha Chain Acts as a HBsAg Binding Protein and their Interaction Promotes HepG2 Cell Apoptosis. Current Proteomics. 11:48-54, 2014.

7

Xiao CX#, Yang XN#, Huang QW, Liu JJ, Liu YP, Jazag A, Guleng B* and Ren JL*(corresponding). ECHS1 acts as a novel HBsAg binding protein and its interaction enhances apoptosis through mitochondrial pathway in HepG2 cells. Cancer letter. 330(1):67-73, 2013. (IF:5.016)

8

Zhang YQ#, Xiao CX#, Lin BY, Shi Y, Liu YP, Liu JJ, Guleng B*, Ren JL*(corresponding). Silencing of Pokemon enhances caspase-dependent apoptosis via fas- and mitochondria-mediated pathways in hepatocellular carcinoma cells. PLoS One. 17; 8(7):e68981, 2013.

9

Wang LY#, Liu YP#, Chen LG, Chen YL, Tan L, Liu JJ, Jazag A, Ren JL*(corresponding), Guleng B*. Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells. PLoS One. 28; 8(6):e67542, 2013.

10

Xiao CX#, Wang HH#, Shi Y, Li P, Liu YP, Ren JL*(corresponding) and Guleng B*. Distribution of bone-marrow-derived endothelial and immune cells in a murine colitis-associated colorectal cancer model. PLoS One. 8(9):e73666, 2013.


11

Lin CC#, Zhou JP#, Liu YP, Liu JJ, Yang XN, Jazag A, Zhang ZP, Guleng B* and Ren JL*(corresponding).The Silencing of pokemon attenuates the proliferation of hepatocellular carcinoma cells in vitro and in vivo by Inhibiting the PI3K/Akt Pathway. PLoS One. 7(12):e51916, 2012.


12

Liu JJ#, Wang X#, Cai YL, Zhou JP, Guleng B, Shi HX and Ren JL*(corresponding). The regulation of trefoil factor 2 expression by the transcription factor Sp3. Biochem Bioph Res Co. 427:410-414, 2012.


13

Liu YP#, Yang XN#, Jazag A, Pan JS, Hu TH, Liu JJ, Guleng B* and Ren JL*(corresponding). HBsAg inhibits the translocation of JTB into mitochondria in HepG2 cells and potentially plays a role in HCC progression. PLoS One. 7(5):e36914, 2012.


14

Tang HL#, Hu YQ#, Qin XP, Jazag A, Yang H, Yang YX, Yang XN, Liu JJ, Chen JM, Guleng B*, Ren JL*(corresponding). Aplasia ras homolog member I is down regulated in gastric cancer and silencing its expression promotes cell growth in vitro. J Gastroenterol Hepato. 27 (8):1395-1404, 2012.


15

Guleng B#, Han J, Yang JQ, Huang QW, Huang JK, Yang XN, Liu JJ, Ren JL*(corresponding). TFF3 mediated induction of VEGF via hypoxia in human gastric cancer SGC-7901 cells. Molecular Biology Reports. 39:4127-4134, 2012.


16

Otsuka M#, Kang YJ, Ren J, Jiang H, Wang Y, Omata M, Han J*. Distinct effects of p38 alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease. Gastroenterology. 138(4):1237-9, 2010.


17

Pan JS#, Zhang ZP#, Cai JY, Dong J, Ren J*(corresponding) and Wang, XZ*. Competitive priming PCR: a versatile method to generate cohesive terminusMolecular Biology Reports. 37(3):1421-1425, 2010.


18

Guleng B*Lian YMRen J*(corresponding). Mindin is upregulated during colitis and may activate NF-kappa B in a TLR-9 mediated manner. World Journal of Gastroenterology. 16(9):1070-1075, 2010.

主持课题:

1

国家自然科学基金面上项目81370591,《miRNA423-5p调控三叶因子表达及在胃肠道粘膜修复中的作用机制》,2014.01-2017.12

2

国家自然科学基金面上项目,30971362,《TFF3结合蛋白的验证及其介导胃癌细胞转移侵袭机制研究》,2010.01-2012.12

3

国家自然科学基金委主任项目,30750013,《三叶因子3 与胃癌转移、侵袭的机制》,2008.01-2008.12

4

国家重大科学研究计划子课题,2013CB944903,《肝脏免疫前体细胞命运决定与分化的分子调控网络 》,2013.1-2015.12

5

973”计划子课题,2009CB522200,《炎症反应的细胞信号转导网络与肿瘤的关系》,2010.01-2013.12


6

厦门市重要重大疾病联合攻关项目,3502Z20149032,《厦门市消化系统肿瘤早诊早治防控体系建设》,2014.01-2017.12

获奖:

1

2014年厦门市科学技术进步奖一等奖,乙型肝炎病毒新变异及临床治疗预测的研究