卜国军

卜国军  “中央千人计划”入选者

职称教授/博导

学科(专业):神经科学、生物学

研究方向:阿尔茨海默病的发病机制和治疗研究

邮箱bu@xmu.edu.cn

电话:0592-2189775


教育背景:

1981-1985,北京师范大学,生物学专业学士

1985-1990,美国弗吉尼亚理工大学,生物化学专业博士


工作经历:

1996-2000,美国华盛顿大学医学院  助理教授

2001-2006,美国华盛顿大学医学院  副教授

2007-2010,美国华盛顿大学医学院 教授

2010年至今,美国梅奥医学院 教授

2011年至今,厦门大学医学院 教授

2006年至今 担任《Molecular Neurodegeneration》杂志(IF: 6.51)共同主编



主要研究领域:

卜国军教授是在低密度脂蛋白受体家族及其相关生物学研究领域世界公认的领军人物之一,他长期致力于研究apoE及其受体调控阿尔茨海默病、癌症以及心血管疾病等发生、发展的病理和生理机制,取得了十分突出的成就。已在Nature MedicineNature NeuroscienceNeuronPNASPLoS Biology等国际一流杂志发表230多篇论文,被引用10000多次,H-index高达62。多次受邀在多种国际会议上作学术报告。并为Nature Reviews Neuroscience, Nature Reviews Neurology, Neuron 等多个权威杂志撰写综述。此外,卜教授还是Molecular Neurodegeneration杂志(SCI影响因子6.51)创办人和共同主编,美国NIH及光明焦点基金会(Bright Focus)科学审查委员会成员。卜教授还获得了多项高声望的学术成就奖励,包括美国心脏协会颁发的杰出研究者奖,阿尔茨海默病协会颁发的Zenith Fellows Award及阿尔茨海默病研究领域最高奖MetLife Award



主要学术成果:

论文/著作/专利:

1

Liu CC, Zhao N, Yamaguchi Y, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G*2016Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease. Sci Transl Med. 8(332):332ra44. (影响因子15.843

2

Liu CC, Hu J, Tsai CW, Yue M, Melrose HL, Kanekiyo T, Bu G* (2015) Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain. J Neurosci. 35:5851-5859.(影响因子7.452

3

Liu CC, Tsai CW, Deak F, Rogers J, Penuliar M, Sung YM, Maher JN, Fu Y, Li X, Xu H, Estus S, Hoe HS, Fryer JD, Kanekiyo T, Bu G* (2014) Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease. Neuron. 84:63-77.(影响因子15.98

4

Kanekiyo T, Xu H, Bu G* (2014) ApoE and Aβ in Alzheimer's disease: accidental encounters or partners? Neuron.81:740-754. (影响因子15.98

5

Liu CC, Kanekiyo T, Xu H, Bu G* (2013) Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol. 9(2):106-118.(影响因子12.461)(ESI热点论文)

6

Kanekiyo T, Cirrito JR, Liu CC, Shinohara M, Li J, Schuler DR, Shinohara M, Holtzman DM, Bu G* (2013). Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1. J Neurosci. 33(49):19276-19283(影响因子7.452

7

Kanekiyo T1, Liu CC, Shinohara M, Li J, Bu G*(2012) LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid-β. J Neurosci. 32(46):16458-65.(影响因子7.452

8

Liu Q, Zhang J, Zerbinatti C, Zhan Y, Kolber BJ, Herz J, Muglia LJ, Bu G* (2011) Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biol. 9(1):e1000575.(影响因子12.683

9

Kanekiyo T, Zhang J, Liu Q, Liu CC, Zhang L, Bu G*(2011) Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-bata uptake J Neurosci.31(5):1644-51.(影响因子7.452

10

Liu CC, Prior J, Piwnica-Worms D, Bu G*(2010) LRP6 overexpression  defines a class of breast cancer subtype and is a target for therapy. Proc. Natl. Acad. Sci. USA.107:5136-5141.(影响因子10.789

11

Liu Q, Trotter J, Zhang J, Peters MM, Cheng H, Bao J, Han X, Weeber EJ,Bu G*(2010)Impaired brain lipid metabolism in lipoprotein receptor-deficient mice leads to progressive, age-dependent synapse loss and neurodegeneration. J Neurosci. 30(50):17068-78.(影响因子7.452

12

Bu G* (2009) Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat Rev Neurosci.10:333-344.(影响因子25.94

13

Song H, Li Y, Lee J, Schwartz AL, Bu G* (2009)Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9. Cancer Res. 69(3):879-86.(影响因子7.514)

14

Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G * (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron.56:66-78.(影响因子15.98

15

van Kerkhof P, Lee J, McCormick L, Tetrault E, Lu W, Schoenfish M, Oorschot V, Strous GJ, Klumperman J, Bu G* (2005) Sorting nexin 17 facilitates LRP recycling in the early endosome. EMBO J. 17;24(16):2851-61.(影响因子10.65

主要课题:

起止时间

项目性质和来源

经费总额

2016.1-2019.12

国家自然科学基金促进海峡两岸科技合作联合基金《阿尔茨海默病中TREM2蛋白的功能研究及靶向药物筛选》(U1505227

215万元

2014.01-2017.12

国家自然科学基金《靶向ApoEAD药物筛选及相关作用机制研究》(81373416

80万元


主要获奖/荣誉称号:

获奖项目

授予单位

获奖时间

Established Investigator Award

美国American Heart Association

2000

Zenith Fellows Award

美国 Alzheimer's Association

2008