Professor: Yalin Wu
Assistant Professor: Yi Liao
Research Specialist: Xinhui Hou
Postgraduate Students: Chunyan Liao, Zhan Gao, Houjian Zhang, Yu Zhu
Age-Related Macular Degeneration and Stargardt’s Disease
Age-related macular degeneration (AMD) is a major cause of severe vision loss and irreversible blindness in middle-aged or elder people throughout the world, and has become a serious public health problem. AMD greatly influences health and life quality of the patients and bring a heavy burden of ideology and economy to individuals and our country. Stargardt’s disease (STGD), also called as juvenile macular degeneration, is an autosomal recessive hereditary disease that primarily occurs in the layer of retinal pigment epithelium. Likewise, tens of thousands of people suffer from complete vision loss due to STGD. Our study is mainly focused on the effect and mechanism of visual cycle dysfunction and lipofuscin buildup in the onset and progression of AMD or STGD, and target prevention and treatment of drugs accordingly.
1. Liu X, Chen J, Liu Z, Li J, Yao K*, and Wu Y*. Potential therapeutic agents against retinal diseases caused by aberrant metabolism of retinoids. Invest. Ophthalmol. Vis. Sci. 2016, 57(3), 1017-1030.
2. Zhang J#, Bai Y#, Qi Y, Zhang Q, Li S, Huang L, Wu Y*, and Li X*. Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration. Cell Death Dis. 2015, 6, e1972.
3. Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y, Naranmandura H, Liu X, and Wu Y*. Involvement of endoplasmic reticulum stress in all-trans-retinal induced retinal pigment epithelium degeneration. Toxicol. Sci. 2015, 143(1), 196-208.
4. Zhao J, Yao K, Jin Q, Jiang K, Chen J, Liu Z, Li J, and Wu Y*. Preparative and biosynthetic insights into pdA2E and isopdA2E, retinal-derived fluorophores of retinal pigment epithelial lipofuscin. Invest. Ophthalmol. Vis. Sci. 2014, 55(12), 8241-8250.
5. Wu Y*, Jin Q, Yao K, Zhao J, Chen J, Wu X, Gan L, Li J, Song X, Liu X, and Cai X. Retinal metabolism in humans induces the formation of an unprecedented lipofuscin fluorophore 'pdA2E'. Biochem. J. 2014, 460(3), 343–352.
6. Li J, Yao K, Yu X, Dong X, Gan L, Luo C, and Wu Y*. Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells. J. Biol. Chem. 2013, 288(50), 35671–35682.
7. Wu Y, Zhou J, Fishkin NE, Rittman BE, and Sparrow JR. Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid. J. Am. Chem. Soc. 2011, 133(4), 849–857.
8. Wu Y, Yanase E, Feng X, Siegel M, and Sparrow JR. Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration. Proc. Natl. Acad. Sci. U.S.A. 2010, 107(16), 7275–7280.
9. Wu Y, Fishkin NE, Pande A, Pande J, and Sparrow JR. Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease. J. Biol. Chem. 2009, 284(30), 20155–20166.