研究领域

本课题组利用基因修饰、多组学分析、结构生物学、先进成像技术等前沿技术研究手段，与医院紧密合作，结合临床资源和多种动物模型，聚焦神经退行性疾病的致病机理研究及其靶向治疗的基础与转化研究。近5年来以第一作者在Nature Cell Biology, Science Translational Medicine, Biological Psychiatry 等期刊发表研究论文多篇。

具体研究方向主要有以下几个方向：

（1）泛素连接酶在神经退行性疾病中的作用机制；

（2）免疫调节异常在神经退行性疾病中的作用机理；

（3）代谢异常在神经退行性疾病中的作用机制。

学习经历

2011~2016  厦门大学医学院 生理学  博士研究生

2007~2011  福建农林大学生命科学学院 生物信息学 理学学士

工作经历

2025~至今 厦门大学医学院  教授

2022~2024 美国约翰霍普金斯大学医学院神经科学系  Research Associate

2016~2022 美国约翰霍普金斯大学医学院神经科学系  博士后

代表性成果

(1) Jiechao Zhou; Yang an Chuang; Javier Redding-Ochoa; Alexander J. Platero; Alexander H. Barrett; Juan C. Troncoso; Paul F. Worley; Wenchi Zhang ; The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation. Nat Cell Biol. 2024 Aug;26(8):1274-1286. doi: 10.1038/s41556-024-01461-4. Epub 2024 Jul 15. PMID: 39009640.

(2) Jiechao Zhou; Sarah D. Wade; David Graykowski; Mei-Fang Xiao; Binhui Zhao; Lucia A. A. Giannini; Jesse E. Hanson; John C. van Swieten; Morgan Sheng; Paul F. Worley; Borislav Dejanovic ; The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration, Science Translational Medicine, 2023, 15(689)

(3) Jiechao Zhou; Hei-Man Chow; Yan Liu; Di Wu; Meng Shi; Jieyin Li; Lei Wen; Yuehong Gao; Guimiao Chen; Kai Zhuang; Hui Lin; Guanyun Zhang; Wenting Xie; Huifang Li; Lige Leng; Mengdan Wang; Naizhen Zheng; Hao Sun; Yingjun Zhao; Yunwu Zhang; Maoqiang Xue; Timothy Y. Huang; Guojun Bu; Huaxi Xu; Zengqiang Yuan; Karl Herrup; Jie Zhang ; Cyclin-Dependent Kinase 5–Dependent BAG3 Degradation Modulates Synaptic Protein Turnover, Biological Psychiatry, 2020, 87(8): 756-769

(4) Zhou, Jiechao; Li, Huifang; Li, Xiaoping; Zhang, Guanyun; Niu, Yaqiong; Yuan, Zengqiang; Herrup, Karl; Zhang, Yun-Wu; Bu, Guojun; Xu, Huaxi; Zhang, Jie ; The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death, JOURNAL OF NEUROSCIENCE, 2015, 6(35): 2624- 2635

获奖及荣誉

1. 国家高层次青年人才，2025年

所有论文列表

(1) Mei-Fang Xiao; Seung-Eon Roh; Jiechao Zhou; Chun-Che Chien; Brendan P. Lucey; Michael T. Craig; Lindsay N. Hayes; Jennifer M. Coughlin; F. Markus Leweke; Min Jia; Desheng Xu; Weiqiang Zhou; C. Conover Talbot; Don B. Arnold; Melissa Staley; Cindy Jiang; Irving M. Reti; Akira Sawa; Kenneth A. Pelkey; Chris J. McBain; Alena Savonenko; Paul F. Worley ; A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function, Science Advances, 2021, 7(48)

(2) Wenchi Zhang; Yang-An Chuang; Youn Na; Zengyou Ye; Liuqing Yang; Raozhou Lin; Jiechao Zhou; Jing Wu; Jessica Qiu; Alena Savonenko; Daniel J.Leahy; Richard Huganir; David J.Linden; Paul F.Worley ; Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation, Molecular Cell, 2019, 75(1)

(3) Daniel Severin; Su Z. Hong; Seung-Eon Roh; Shiyong Huang; Jiechao Zhou; Michelle C. D. Bridi; Ingie Hong; Sachiko Murase; Sarah Robertson; Rebecca P. Haberman; Richard L. Huganir; Michela Gallagher; Elizabeth M. Quinlan; Paul Worley; Alfredo Kirkwood ; All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity, Proceedings of the National Academy of Sciences, 2021, 118(37)

(4) Guo, Dong; Xie, Wenting; Xiong, Pan; Li, Huifang; Wang, Siqi; Chen, Guimiao; Gao, Yuehong; Zhou, Jiechao; Zhang, Ye; Bu, Guojun; Xue, Maoqiang; Zhang, Jie ; Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress- induced neuronal death, CELL DEATH & DISEASE, 2018, 9(9): 951

(5) Hei-Man Chow; Dong Giuo; Jiechao Zhou; Zhang, Guan-Yun; Li, Hui-Fang; Herrup, Karl; Zhang, Jie ; CDK5 activator protein p25 preferentially binds and activates GSK3beta., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(45): E4887-E4895

(6) Zhang, Jie; Li, Huifang; Zhou, Tingwen; Zhou, Jiechao; Herrup, Karl ; Cdk5 Levels Oscillate during the Neuronal Cell Cycle Cdh1 UBIQUITINATION TRIGGERS PROTEOSOME-DEPENDENT DEGRADATION DURING S-PHASE, Journal of Biological Chemistry, 2012, 287(31): 25985-25994

(7) Fuqiang Wang; Wenxing Zhao; Yuehong Gao; Jiechao Zhou; Huifang Li; Guanyun Zhang; Dong Guo; Chengrong Xie; Jie Li; Zhenyu Yin; Jie Zhang ; CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis, Journal of Experimental & Clinical Cancer Research, 2019, 38(1): 1-15

(8) L.Cao; J.Zhou; J.Zhang; S.Wu; X.Yang; X.Zhao; H.Li; M.Luo; Q.Yu; G.Lin; H.Lin; J.Xie; P.Li; X.Hu; C.Zheng; G.Bu; Y.-w.Zhang; H.Xu; Y.Yang; C.Huang; J.Zhang ; Cyclin-Dependent Kinase 5 Decreases in Gastric Cancer and Its Nuclear Accumulation Suppresses Gastric Tumorigenesis, Clinical Cancer Research, 2015, 21(6): 1419-1428

(9) Chen X.; Zhang W.; Zhang B.; Zhou J.; Wang Y.; Yang Q.; Ke Y.; He H ; Phosphoproteins regulated by heat stress in rice leaves, Proteome Science, 2011, 9(37): 1-9