研究领域：

主要从事肿瘤核受体信号转导及靶向药物研发工作。围绕核受体及其下游分子在肿瘤生长转移过程中的作用、调控机制和信号网络开展系列研究，重点集中在转录调控、生物大分子互作以及蛋白翻译后修饰的功能调控，与临床紧密结合并研发相关靶向药物。近年来以第一/通讯作者（含共同）在Nature Chemical Biology、Nature Communications、Cell Reports、Cancer Research、Molecular Cancer等SCI杂志发表论文19篇。作为主要参与者（排名第三）获2012年度福建省自然科学奖一等奖。主持国家自然科学基金4项、福建省科技项目5项（含福建省杰出青年基金）以及厦门市科技项目2项。

学习经历：

2000/09~2004/07 厦门大学生命科学学院生物科学专业   理学学士

2004/09~2010/12 厦门大学生命科学学院细胞生物学专业   理学博士

工作经历：

2011/02~2013/02   厦门大学附属第一医院   博士后

2013/04~2024/07   厦门大学医学院   副教授

2022/11~2023/10   厦门市思明区卫生健康局   副局长（挂职）

2024/08~至今    厦门大学医学院   教授

代表性成果（#第一作者, *通讯作者）：

1.Hou J^#, Mei K^#, Wang D^#, Ke S, Chen X, Shang J, Li G, Gao Y, Xiong H, Zhang H, Chen L, Zhang W, Deng Y, Hong X, Liu DA, Hu T*, Guo W*, Zhan YY*. TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation. Cell Reports, 2024 Aug 27;43(8):114604.

2.Hou J^#, Wu H^#, Xu B, Shang J, Xu X, Li G, Zhang H, Zhang W, Deng Y, Hong X, Hu T, Zhang M*, Zhan Y*. The Prognostic Value and the Oncogenic and Immunological Roles of Vacuolar Protein Sorting Associated Protein 26 A in Pancreatic Adenocarcinoma. International Journal of Molecular Sciences. 2023 Feb 9;24(4):3486.

3.Chen X^#, Zhao Y^#, Wang D^#, Lin Y, Hou J, Xu X, Wu J, Zhong L, Zhou Y, Shen J, Zhang W, Cao H, Hong X, Hu T, Zhan YY*. The HNF4α-BC200-FMR1-Positive Feedback Loop Promotes Growth and Metastasis in Invasive Mucinous Lung Adenocarcinoma. Cancer Research, 2021 Dec 1;81(23):5904-5918.

4.Mao L^#, Zhan YY^#,*, Wu B^#, Yu Q^#, Xu L, Hong X, Zhong L, Mi P, Xiao L, Wang X, Cao H, Zhang W, Chen B, Xiang J, Mei K, Radhakrishnan R, Guo W*, and Hu T*. ULK1 phosphorylates Exo70 to suppress breast cancer metastasis. Nature Communications, 2020 Jan 8;11(1):117.

5.Xu B^#, Jiang X^#, Xiong J, Lan J, Zhong L, Wang X, Cao H, Zhan YY*, Zhang Y* and Hu T*, Structure-activity relationship study enables the discovery of a novel berberine analogue as RXRα activator to inhibit colon cancer. Journal of Medicinal Chemistry, 2020 Jun 11;63(11):5841-5855.

6.Hong X^#, Zhong L^#, Xie Y, Zheng K, Pang J, Li Y, Yang Y, Xu X, Mi P, Cao H, Zhang W, Hu T, Song G*, Wang D* and Zhan YY*. Matrine reverses the Warburg effect and suppresses colon cancer cell growth via negatively regulating HIF-1α. Frontiers in Pharmacology, 2019 Nov 28;10:1437.

7.Li D^#, Xiao L^#, Ge Y, Fu Y, Zhang W, Cao H, Chen B, Wang H*, Zhan YY*, Hu T*. High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer. Molecular Cancer, 2018 Nov 17;17(1):159.

8.Ruan H^#, Zhan YY^#,*, Hou J, Xu B, Chen B, Tian Y, Wu D, Zhao Y, Zhang Y, Chen X, Mi P, Zhang L, Zhang S, Wang X, Cao H, Zhang W, Wang H, Li H, Su Y, Zhang XK* and Hu T*. Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells. Oncogene, 2017 Aug 28;36(50):6906-6918.

9.Li D, Zhang Y, Liu K, Zhao Y, Xu B, Xu L, Tan L, Tian Y, Li C, Zhang W, Cao H, Zhan YY*, Hu T*. Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth. Laboratory Investigation, 2017 Jul 31; 97(11):1343-1353.

10.Xu B^#, Xu M^#, Tian Y, Yu Q, Zhao Y, Chen X, Mi P, Cao H, Zhang B, Song G, Zhan YY*, Hu T*. Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells. Cell Death Discovery, 2017 Jan 23;3:16096.

11.Zhao Y, Hou J, Mi P, Mao L, Xu L, Zhang Y, Xiao L, Cao H, Zhang W, Zhang B, Song G, Hu T*, Zhan YY*. Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells. Oncotarget, 2016 Feb 23;7(8):9150-62.

12.Zhou H^#, Xu M^#, Gao Y, Deng Z, Cao H, Zhang W, Wang Q, Zhang B, Song G*, Zhan Y*, Hu T*. Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor. Molecular Cancer, 2014 Mar 16, 13:59.

13.Zhan YY^#, He JP^#, Chen HZ, Wang WJ, Cai JC*. Orphan receptor TR3 is essential for the maintenance of stem-like properties in gastric cancer cells. Cancer Letters, 2013 Feb 1, 329(1): 37-44.

14.Zhan YY^#, Chen Y^#, Zhang Q^#, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T*, Wu Q*. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nature Chemical Biology, 2012 Nov, 8(11): 897-904.

15.Zhan Y^#, Du X^#, Chen H, Liu J, Zhao B, Huang D, Li G, Xu Q, Zhang M, Weimer BC, Chen D, Cheng Z, Zhang L, Li Q, Li S, Zheng Z, Song S, Huang Y, Ye Z, Su W, Lin SC*, Shen Y*, Wu Q*. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nature Chemical Biology, 2008 Sep; 4(9): 548-56.

主持过的重要课题：

1.国家自然科学基金面上项目，2024/01-2027/12

2.福建省省属科研院所公益类项目，2024/05-2026/04

3.福建省自然科学基金重点项目，2022/08-2025/08

4.国家自然科学基金面上项目，2021/01-2024/12

5.福建省省属科研院所公益类项目，2021/08-2023/08

6.厦门市科技局青年创新基金项目，2020/07-2023/07

7.福建省自然科学基金杰出青年项目，2017/04-2020/04

8.国家自然科学基金面上项目，2016/01-2019/12

9.福建省省属科研院所公益类项目面上项目，2017/04-2019/04

10.厦门市卫计委重要重大疾病联合攻关项目，2016/01-2018/12

11.福建省省属科研院所公益类项目，2015/01-2016/12

12.国家自然科学基金青年项目，2014/01-2016/12

13.中国博士后科学基金面上资助，2012/09-2013/03