赵干 教授，博士生导师
国家高层次青年人才/厦门大学南强青年拔尖A类人才 研究方向：肺再生修复机制和治疗手段 所在系部：福建省器官与组织再生重点实验室邮 箱：zhaogan@xmu.edu.cn |  |
研究领域
病毒性肺炎，尤其新型冠状病毒肺炎（COVID-19）的全球爆发，对公共卫生和医疗系统造成了深远影响。本课题组长期致力于病毒性肺损伤的修复机制及新型治疗策略研究，依托厦门大学附属医院的临床资源，结合多能干细胞（iPSCs）定向分化、类器官培养、CRISPR-Cas9基因编辑、单细胞转录组/高通量转录组学分析、高分辨率显微成像及疾病动物模型等前沿技术，深入探究呼吸系统疾病的发病机制、组织修复过程及靶向干预策略。近年来，课题组负责人以第一作者（含共同）和通讯作者（含共同）身份在Science Translational Medicine、Science Advances、Nature Nanotechnology、Nature Communications、PNAS等国际高水平期刊发表多篇研究论文。
主要研究方向包括：
1. 肺血管内皮细胞再生机制及其在肺功能恢复中的作用；
2. 免疫微环境介导的调控肺再生修复的分子机制；
3. 肺再生修复关键靶点的筛选及新型治疗策略开发。
学习经历
2014~2020 华中农业大学 动物科技-动物医学学院 农学博士；
2018~2020 美国宾夕法尼亚大学 肺生物学研究所 博士联合培养；
2009~2014 华中农业大学 动物科技-动物医学学院 农学学士。
工作经历
2025~至今 厦门大学 医学院/附属第一医院 教授；
2020~2025 美国宾夕法尼亚大学 肺生物学研究所 博士后；
代表性成果（#共同第一作者；*通讯作者）
1.Zhao G#, Xue L#, Weiner AI, Gong N, Adams-Tzivelekidis S, Wong J, Gentile ME, Nottingham AN, Basil MC, Lin SM, Niethamer TK, Diamond JM, Bermudez CA, Cantu E, Han X, Cao Y, Alameh MG, Weissman D, Morrisey EE, Mitchell MJ, Vaughan AE*. TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue. Sci Transl Med. 2024 Jan 31;16(732):eadg6229.
2.Zhao G, Weiner AI, Neupauer KM, de Mello Costa MF, Palashikar G, Adams-Tzivelekidis S, Mangalmurti NS, Vaughan AE*. Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2. Sci Adv. 2020 Nov 25;6(48):eabc4493.
3.Zhao G*, Gentile ME, Xue L, Cosgriff CV, Weiner AI, Adams-Tzivelekidis S, Wong J, Li X, Kass-Gergi S, Holcomb NP, Basal MC, Stewart KM, Planer JD, Cantu E, Christie JD, Crespo MM, Mitchell MJ, Meyer NJ, Vaughan AE*. Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation. Nat Commun. 2024 May 18;15(1):4235.
4.Zhao G#, Xue L#, Geisler HC, Xu J, Li X, Mitchell MJ*, Vaughan AE*. Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2314747121.
5.Xue L#, Zhao G#, Gong N#, Han X, Shepherd SJ, Xiong X, Xiao Z, Palanki R, Xu J, Swingle KL, Warzecha CC, El-Mayta R, Chowdhary V, Yoon IC, Xu J, Cui J, Shi Y, Alameh MG, Wang K, Wang L, Pochan DJ, Weissman D, Vaughan AE, Wilson JM, Mitchell MJ*. Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery. Nat Nanotechnol. 2025 Jan;20(1):132-143.
获奖及荣誉
国家高层次青年人才，2025年
学术兼职
Research、The Innovation Life以及Cell Proliferation 青年编委
Frontiers in Immunology 副编辑（Associate Editor）
其他论文列表
1.Jones DL, Morley MP, Li X, Ying Y, Zhao G, Schaefer SE, Rodriguez LR, Cardenas-Diaz FL, Li S, Zhou S, Chembazhi UV, Kim M, Shen C, Nottingham A, Lin SM, Cantu E, Diamond JM, Basil MC, Vaughan AE, Morrisey EE*. An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung. Science. 2024 Dec 13;386(6727):eado5561.
2.Wong J, Zhao G, Adams-Tzivelekidis S, Wen H, Chandrasekaran P, Michki SN, Gentile ME, Singh M, Kass-Gergi S, Mendoza M, Holcomb NP, Li X, Tang AT, Negretti NM, Sucre JMS, Frank DB*, Vaughan AE*. Dynamic behavior and lineage plasticity of the pulmonary venous endothelium. Nat Cardiovasc Res. 2024 Dec;3(12):1584-1600.
3.Weiner AI, Zhao G, Zayas HM, Holcomb NP, Adams-Tzivelekidis S, Wong J, Gentile ME, Reddy D, Wei J, Palashikar G, Quansah KK, Vaughan AE*. ΔNp63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung injury. Cell Rep. 2022 Dec 13;41(11):111805.
4.Niethamer TK#, Planer JD#, Morley MP, Babu A, Zhao G, Basil MC, Cantu E, Frank DB, Diamond JM, Nottingham AN, Li S, Sharma A, Hallquist H, Levin LI, Zhou S, Vaughan AE, Morrisey EE*. Longitudinal single-cell profiles of lung regeneration after viral infection reveal persistent injury-associated cell states. Cell Stem Cell. 2025 Feb 6;32(2):302-321.e6.
5.Xue L, Hamilton AG, Zhao G, Xiao Z, El-Mayta R, Han X, Gong N, Xiong X, Xu J, Figueroa-Espada CG, Shepherd SJ, Mukalel AJ, Alameh MG, Cui J, Wang K, Vaughan AE, Weissman D, Mitchell MJ*. High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Nat Commun. 2024 Feb 29;15(1):1884.
6.Xue L, Xiong X, Zhao G, Molina-Arocho W, Palanki R, Xiao Z, Han X, Yoon IC, Figueroa-Espada CG, Xu J, Gong N, Shi Q, Chen Q, Alameh MG, Vaughan AE, Haldar M, Wang K, Weissman D, Mitchell MJ*. Multiarm-Assisted Design of Dendron-like Degradable Ionizable Lipids Facilitates Systemic mRNA Delivery to the Spleen. J Am Chem Soc. 2025 Jan 15;147(2):1542-1552.
7.Weiner AI, Jackson SR, Zhao G, Quansah KK, Farshchian JN, Neupauer KM, Littauer EQ, Paris AJ, Liberti DC, Scott Worthen G, Morrisey EE, Vaughan AE*. Mesenchyme-free expansion and transplantation of adult alveolar progenitor cells: steps toward cell-based regenerative therapies. NPJ Regen Med. 2019 Aug 20;4:17.
8.Kass-Gergi S, Zhao G, Wong J, Weiner AI, Adams Tzivelekidis S, Gentile ME, Mendoza M, Holcomb NP, Li X, Singh M, Huang Y, Klochkova A, Vaughan AE*. Disruption of immune responses by type 1 diabetes exacerbates SARS-CoV-2 mediated lung injury. Am J Physiol Lung Cell Mol Physiol. 2024 Dec 1;327(6):L839-L851.
9.Rane CK, Jackson SR, Pastore CF, Zhao G, Weiner AI, Patel NN, Herbert DR*, Cohen NA*, Vaughan AE*. Development of solitary chemosensory cells in the distal lung after severe influenza injury. Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1141-L1149.
10.Sierra I, Pyfrom S, Weiner A, Zhao G, Driscoll A, Yu X, Gregory BD, Vaughan AE, Anguera MC. Unusual X chromosome inactivation maintenance in female alveolar type 2 cells is correlated with increased numbers of X-linked escape genes and sex-biased gene expression. Stem Cell Reports. 2023 Feb 14;18(2):489-502.
11.Xue L#, Gong N#, Shepherd SJ, Xiong X, Liao X, Han X, Zhao G, Song C, Huang X, Zhang H, Padilla MS, Qin J, Shi Y, Alameh MG, Pochan DJ, Wang K, Long F, Weissman D, Mitchell MJ*. Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment. J Am Chem Soc. 2022 Jun 8;144(22):9926-9937.
12.Han X, Alameh MG, Gong N, Xue L, Ghattas M, Bojja G, Xu J, Zhao G, Warzecha CC, Padilla MS, El-Mayta R, Dwivedi G, Xu Y, Vaughan AE, Wilson JM, Weissman D*, Mitchell MJ*. Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo. Nat Chem. 2024 Oct;16(10):1687-1697.
13.Han X#, Xu J#, Xu Y, Alameh MG, Xue L, Gong N, El-Mayta R, Palanki R, Warzecha CC, Zhao G, Vaughan AE, Wilson JM, Weissman D, Mitchell MJ*. In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors. Nat Commun. 2024 Feb 26;15(1):1762.
14.Shiraishi K, Morley MP, Jones DL, Zhao G, Weiner AI, Basil MC, Cantu E, Ferguson LT, Oyster M, Babu A, Ying Y, Zhou S, Li S, Vaughan AE, Morrisey EE*. Airway epithelial cell identity and plasticity are constrained by Sox2 during lung homeostasis, tissue regeneration, and in human disease. NPJ Regen Med. 2024 Jan 5;9(1):2.
