研究领域

长期从事环境毒理与健康研究，围绕阐明人工纳米材料暴露诱导的毒性效应和机制的科学问题，利用计算机预测、细胞高通量筛选、类器官、斑马鱼和哺乳动物毒性效应筛查研究手段，探明了典型纳米材料毒性的影响因素及其机理，深入研究发现了典型纳米材料毒性效应的新机制，并取得了一系列成果：以第一或通讯作者(均含共同)在Adv Sci、Nano Today、Small、Small Methods、Environ Sci Tech、J Hazard Mater、Theranostics、Arch Toxicol、Cell Death Dis、J Biol Chem等杂志发表SCI论文40余篇。以第一发明人申请国家专利3项。

主持国家自然科学基金青年基金1项、面上项目2项，财政部中央本级重大增减支项目子课题1项，省级基金项目3项等；参与国家重点研发计划项目1项。主要开展以下三方面研究工作：

1. 利用环境分析化学、环境流行病学手段，探明纳米颗粒等环境污染物环境和人体负荷，探索其与生殖、发育、代谢疾病等不良健康结局的关联。

2. 通过构建的计算机预测、细胞、类器官、转基因和基因敲除斑马鱼、小鼠等动物等毒性评价体系，开展纳米颗粒等环境污染物的健康风险与毒性效应、毒理机制研究。

3. 针对环境污染物诱发的生殖、发育、代谢疾病等不良健康结局，采用天然产物、中药活性成分、纳米药物等进行预防和干预，探索减轻环境污染健康风险的干预策略和方法。

学习经历

2003/09-2007/06，南京农业大学，无锡渔业学院，本科

2007/09–2012/12，厦门大学，生命科学学院生物学系，博士

2011/09–2012/08, Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, USA国家留学基金委公派联合培养博士

工作经历

2013/01–2017/07，厦门大学，公共卫生学院预防医学系，助理教授

2017/08–2018/07，厦门大学，公共卫生学院预防医学系，副教授

2018/08–2024/07，厦门大学，生命科学学院生物学系，副教授

2024/08–至 今，厦门大学，生命科学学院生物学系，教授

学术兼职

1. 中国毒理学青年委员会委员

2. 中国毒理学青年工作委员会委员

3. 中国环境诱变剂学会环境与表观遗传学专业委员会委员

4. 中国环境诱变剂学会环境与发育源性疾病专业委员会委员

5. 中国中药协会中药材检测认证技术专业委员会委员

6. The Innovation青年编委

7. Chemical Journal of Chinese Universities青年编委

8. 中国毒理学会第九次全国青年科技大会，分会场召集人、主持人2023

9. 第九届全国生态毒理学大会，分会场召集人2024

10. 第九届青年地学论坛，分会场召集人2024

科研项目

1. 国家自然科学基金面上项目，22376174，利用斑马鱼模型研究量子点纳米材料暴露诱发视觉发育毒性及机制，2024/01-2027/12，在研，主持

2. 国家自然科学基金面上项目，32071301，Kyn/AhR通路调控T细胞活化促进黑磷量子点诱导肾脏损伤的分子机制，2021/01-2024/12，在研，主持

3. 国家自然科学基金青年项目，81402648，多环芳烃通过NO介导的亚硝基化影响海马神经发育的机制研究，2015/01-2017/12，已结题，主持

4. 翔安创新实验室开放课题，碳纳米优化基质胶促类器官成熟体系的研发及应用，2023/12-2024/12，在研，主持

5. 财政部2021年中央本级重大增减支项目课题，206030203，名贵中药资源可持续利用能力建设子课题——利用斑马鱼模型研究进口紫草中吡咯里西啶生物碱的生物安全性及机制，2021/8-2023/12，在研，主持

6. 福建省自然科学基金面上项目，2020J01027，黑磷量子点小鼠肾脏损伤效应及机制研究，2020/11-2023/11，已结题，主持

7. 厦门大学校长基金，20720180045，未折叠蛋白反应ATF4通路调控内质网自噬介导量子点肾损伤机制研究与应用，2018/1-2020/12，已结题，主持

8. 国家重点研发计划，2017YFA0205201，“肝癌高特异性近红外纳米成像探针的设计与合成”，2017/07-2022/06，已结题，参加

9. 福建省自然科学基金社会发展高校产学合作项目，2021Y4006，荷蓬茶源素对高尿酸血症预防和缓解作用研究及应用示范，2021/10-2024/9，在研，参加

代表性论文(# co-first author, * Corresponding author)

10篇代表性科研论文（ #第一作者； *通讯作者）：

1. Naying Zheng, Tingting Liao, Chuchu Zhang, Zheyang Zhang, Sen Yan, Xiaohan Xi, Fengkai Ruan, Chunyan Yang, Qingliang Zhao, Wenbo Deng, Jialiang Huang, Zi-Tao Huang, Zhi-Feng Chen, Xiang Wang, Qingming Qu, Zhenghong Zuo *, Chengyong He *. Quantum Dots-caused Retinal Degeneration in Zebrafish Regulated by Ferroptosis and Mitophagy in Retinal Pigment Epithelial Cells through Inhibiting Spliceosome. Advanced Science. 2024:e2406343.

2. Fengkai Ruan, Jie Zeng, Changqian Liu, Jianrong Han, Naying Zheng, Kun Li, Hanying Yin, Mingtao Wu, Xiaoyan Ding, Changshun Han, Dai Wang, Lingtao Yang, Chunyan Yang, Nengming Xiao, Zhenghong Zuo *, Chengyong He *. Gut microbiota dysbiosis mediates mouse kidney fibrosis induced by black phosphorus quantum dots. Nano Today. 2024;55:102203.

3. Chengyong He # *, Fengkai Ruan #, Shengwei Jiang #, Jie Zeng, Hanying Yin, Rong Liu, Yongxing Zhang, Laiqiang Huang, Chonggang Wang, Shaohua Ma *, Zhenghong Zuo *. Black Phosphorus Quantum Dots Cause Nephrotoxicity in Organoids, Mice and Human Cells. Small. 2020;2001371.

4. Haoxing Cai, Mingyue Chen, Yang Gao, Jinpeng Ruan, Chengyong He *, and Zhenghong Zuo *. Transgenerational Effects and Mechanisms of Tributyltin Exposure on Neurodevelopment in the Male Offspring of Rats. Environmental Science & Technology. 2023;57:10201-10210.

5. Ruan #, Jie Zeng #, Hanying Yin #, Shengwei Jiang, Xisen Cao, Naying Zheng, Changshun Han, Chuchu Zhang, Zhenghong Zuo *, Chengyong He *. RNA m6A Modification Alteration by Black Phosphorus Quantum Dots Regulates Cell Ferroptosis: Implications for Nanotoxicological Assessment. Small Methods. 2021;5(3):e2001045.

6. Mingyue Chen #, Chengyong He #, Kongyang Zhu, Zihan Chen, Zixiao Meng, Xiaoming Jiang, Jiali Cai, Chunyan Yang, Zhenghong Zuo *. Resveratrol ameliorates polycystic ovary syndrome via transzonal projections within oocyte-granulosa cell communication. Theranostics. 2022;12(2):782-795. (Cover Story)

7. Fengkai Ruan, Rong Liu, Jie Zeng, Kai Wang, Zhenghong Zuo, Chengyong He *, Yongxing Zhang *. Cytotoxicity of black phosphorus quantum dots on lung-derived cells and the underlying mechanisms. Journal of Hazardous Materials. 2021;402:122875.

8. Fengkai Ruan, Changqian Liu, Yi Wang, Xisen Cao, Zhen Tang, Jiaying Xu, Jie Zeng, Hanying Yin, Naying Zheng, Chunyan Yang, Zhenghong Zuo, Chengyong He *. Role of RNA m6A modification in titanium dioxide nanoparticle-induced acute pulmonary injury: An in vitro and in vivo study. Environmental Pollution. 2022;311:119986.

9. Naying Zheng #, Xiaolian Sun #, Yiyue Shi #, Luheng Chen, Luanjin Wang, Haoxing Cai, Changshun Han, Tingting Liao, Chunyan Yang, Zhenghong Zuo, Chengyong He *. The valence state of iron-based nanomaterials determines the ferroptosis potential in a zebrafish model. Science of The Total Environment. 2023:855:158715.

10. Fengkai Ruan, Changqian Liu, Jie Zeng, Fucong Zhang, Yu Jiang, Zhenghong Zuo, Chengyong He *. Multi-omics integration identifies ferroptosis involved in black phosphorus quantum dots-induced renal injury. Science of the Total Environment. 2024;947:174532.

其他一作/通讯论文：

2024

11. Changqian Liu, Fengkai Ruan, Zhiyuan Chen, Jianrong Han, Xiaoyan Ding, Changshun Han, Lingxiao Ye, Chunyan Yang, Yi Yu, Zhenghong Zuo, Chengyong He *. Phenanthrene-induced hyperuricemia with intestinal barrier damage and the protective role of theabrownin: modulation by gut microbiota-mediated bile acid metabolism. Science of the Total Environment. 2024;949:174923.

12. Luanjin Wang, Cixin Liang, Naying Zheng, Chunyan Yang, Sen Yan, Xiang Wang, Zhenghong Zuo, Chengyong He *. Kidney injury contributes to edema of zebrafish larvae caused by quantum dots. Science of The Total Environment. 2024;908:168420.

13. Changshun Han #, Chengyong He #, Xiaoyan Ding, Zixuan Li, Tianyun Peng, Chensong Zhang, Haibing Chen, Zhenghong Zuo, Jiyi Huang *, and Weiping Hu *. WWC1 upregulation accelerates hyperuricemia by reduction in renal uric acid excretion through Hippo signaling pathway. Journal of Biological Chemistry. 2024;300(8):107485.

14. Jianrong Han, Fengkai Ruan, Chunyan Yang, Zhenghong Zuo, Zonghong Liu *, Chengyong He *. Subacute exposure to black phosphorus quantum dots induces cardiac fibrosis and the potential role of gut microbiota. Journal of Environmental Sciences. 2024. https://doi.org/10.1016/j.jes.2024.03.049.

15. Shuo Huang, Jingyi Wang, Tingting Lin, Chengyong He *, Zhiyuan Chen *. Esketamine Exposure Impairs Cardiac Development and Function in Zebrafish Larvae. Toxics. 2024;12(6):427.

2023

16. Tingting Lin, Li Zhou, Zhibin Chen, Luanjin Wang, Jian Yang, Sheng Wang, Xintan Chen, Zhenghong Zuo, Chengyong He *, Lanping Guo *. Exposure to echimidine impairs the heart development and function of zebrafish larvae. Ecotoxicology and Environmental Safety. 2023;266:115574.

17. Meifang Wu #, Naying Zheng #, Xiaoxiao Zhan, Jianzhang He, Min Xiao, Zhenghong Zuo, Chengyong He *. Icariin induces developmental toxicity via thyroid hormone disruption in zebrafish larvae. Food and Chemical Toxicology. 2023;182:114155.

18. Hanying Yin, You Gao, Weiguang Chen, Chen Tang, Zihan Zhu, Kun Li, Siyu Xia, Changshun Han, Xiaoyan Ding, Fengkai Ruan, Hanrui Tian, Changfeng Zhu, Suyuan Xie, Zhenghong Zuo, Lixin Liao *, Chengyong He *. Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species. Discover Nano. 2023;18(1):101.

2022

19. Jie Zeng, Fengkai Ruan, Mingtao Wu, Jiaying Xu, Zhenghong Zuo, Yi Yu *, Chengyong He *. Black phosphorus quantum dots cause glucose metabolism disorder and insulin resistance in mice. Ecotoxicology and Environmental Safety. 2022;246:114168.

20. Songwen Ren #, You Gao #, Luanjin Wang, Ce Qiu, Lingtao Yang, Li Li, Yueyue Xiao, Nengming Xiao, Lixin Liao, Zhenghong Zuo, Chunyan Yang *, Chengyong He *. Sacran polysaccharide improves atopic dermatitis through inhibiting Th2 type immune response. Life Sciences. 2022;288:120205.

21. Yi Wang, Fengkai Ruan, Zhenghong Zuo, Chengyong He *. Nanoparticle-Induced m6A RNA Modification: Detection Methods, Mechanisms and Applications. Nanomaterials. 2022;12(3): 389.

2021

22. Naying Zheng, Jinhui Yan, Wang Qian, Chao Song, Zhenghong Zuo, Chengyong He *. Comparison of developmental toxicity of different surface modified CdSe/ZnS QDs in zebrafish embryos. Journal of Environmental Sciences. 2021;100:240-249.

23. Junxia Shi, Chenyu Liu, Mingyue Chen, Jinhui Yan, Chonggang Wang, Zhenghong Zuo *, Chengyong He *. The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells. Environmental Toxicology. 2021;36(4):665-674.

24. Kongyang Zhu #, Chao Shen #, Chen Tang, Yixi Zhou, Chengyong He *, Zhenghong Zuo *. Improvement in the screening performance of potential aryl hydrocarbon receptor ligands by using supervised machine learning. Chemosphere. 2021;265:129099.

25. Yixi Zhou, Xue Han, Yuanyuan Bao, Zihan Zhu, Jiali Huang, Chunyan Yang, Chengyong He *, Zhenghong Zuo *. Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma). Aquatic Toxicology. 2021;238:105917.

2020

26. Chen Tang, Chao Shen, Kongyang Zhu, Yixi Zhou, Yung-Jen Chuang, Chengyong He *, Zhenghong Zuo *. Exposure to the AhR agonist cyprodinil impacts the cardiac development and function of zebrafish larvae. Ecotoxicology and Environmental Safety. 2020;201:110808.

27. Jinhui Yan, Shujing Chen, Zhenghong Zuo, Chengyong He *, Muqing Yi *. Graphene oxide quantum dot exposure induces abnormalities in locomotor activities and mechanisms in zebrafish (Danio rerio). Journal of Applied Toxicology. 2020;40:794–803.

2019

28. Chuanli Yang, Peiyu Han, Fengkai Ruan, Tengjian Zhou, Bing Luo, Yang Qiu, Yuchun Lin, Zhongning Lin *, Chengyong He *. Lactational exposure to environmentally relevant benzo(a)pyrene causes astrocytic activation and anxiety-like behavior in male mice. Chemosphere. 2019;221: 67e74.

29. Zhibing Yang, Junxia Shi, Zhizhun Guo, Mingyue Chen, Chonggang Wang, Chengyong He *, Zhenghong Zuo *. A pilot study on polycystic ovarian syndrome caused by neonatal exposure to tributyltin and bisphenol A in rats. Chemosphere. 2019;231:151-160.

30. Chengyong He #, Shengwei Jiang #, Huan Yao #, Liyin Zhang, Chuanli Yang, Shan Jiang, Fengkai Ruan, Denglin Zhan, Gang Liu, Zhongning Lin *, Yuchun Lin *, Xiaoyuan Chen. High-content analysis for mitophagy response to nanoparticles: A potential sensitive biomarker for nanosafety assessment. Nanomedicine-Nanotechnology Biology and Medicine. 2019;15(1):59-69.

2018及以前

31. Shengwei Jiang #, Yuchun Lin #, Huan Yao #, Chuanli Yang, Liyin Zhang, Bing Luo, Zhao Lei, Liwei Cao, Naibo Lin, Xiangyang Liu *, Zhongning Lin *, Chengyong He *. The role of unfolded protein response and ER-phagy in quantum dots-induced nephrotoxicity: an in vitro and in vivo study. Archives of Toxicology. 2018;92(541):1-14.

32. Chengyong He #, Yang Qiu #, Peiyu Han #, Yuanyuan Chen, Liyin Zhang, Quan Yuan, Tianying Zhang, Tong Cheng, Lunzhi Yuan, Chenghao Huang, Sheng Zhang, Zhenyu Yin, Xian-E Peng, Dong Liang, Xu Lin, Yuchun Lin *, Zhongning Lin *, and Ningshao Xia. ER stress regulating protein phosphatase 2A-B56γ, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes. Cell Death & Disease. 2018;9(7):762.

33. Chengyong He #, Shengwei Jiang #, Huan Yao #, Liyin Zhang, Chuanli Yang, Denglin Zhan, Gan Lin, Yun Zeng, Yankai Xia, Zhongning Lin *, Gang Liu *, Yuchun Lin *. Endoplasmic reticulum stress mediates inflammatory response triggered by ultra-small superparamagnetic iron oxide nanoparticles in hepatocytes. Nanotoxicology. 2018;12(10): 1198-1214.

34. Mei Chen #, Shuzhen Chen #, Chengyong He #, Shiguang Mo, Xiaoyong Wang, Gang Liu *, and Nanfeng Zheng *, Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging. Nano Research. 2017;10(4): 1234–1248.

35. Chengyong He #, Shengwei Jiang #, Haijing Jin #, Shuzhen Chen, Gan Lin, Huan Yao, Xiaoyong Wang, Peng Mi, Zhiliang Ji, Yuchun Lin *, Zhongning Lin *, Gang Liu *. Mitochondrial electron transport chain identified as a novel molecular target of SPIO nanoparticles mediated cancer-specific cytotoxicity. Biomaterials. 2016;83:102-114.

36. Bing Luo #, Yuchun Lin #, Shengwei Jiang, Lianyun Huang, Huan Yao, Qunying Zhuang, Ran Zhao, Hengchuan Liu, Chengyong He *, Zhongning Lin *. Endoplasmic reticulum stress eIF2α-ATF4 pathway-mediated cyclooxygenase-2 induction regulates cadmium-induced autophagy in kidney. Cell Death & Disease. 2016;7:e2251.

37. Chengyong He, Zhenghong Zuo, Xiao Shi, Lingbin Sun, Chonggang Wang *, Pyrene exposure influences the thyroid development of Sebastiscus marmoratus embryos. Aquatic Toxicology. 2012:124-125C;28-33.

38. Chengyong He, Chonggang Wang, Bowen Li, Meifang Wu, Hong Geng, Yixin Chen, Zhenghong Zuo *. Exposure of Sebastiscus marmoratus embryos to pyrene results in neurodevelopmental defects and disturbs related mechanisms. Aquatic Toxicology. 2012;116-117: 109-115.

39. Chengyong He, Zhenghong Zuo, Xiao Shi, Ruixia Li, Donglei Chen, Xin Huang, Yixin Chen, Chonggang Wang *. Effects of Benzo(a)Pyrene on the skeletal development of Sebastiscus marmoratus embryos and the molecular mechanism involved. Aquatic Toxicology. 2011;101:335–341.

40. Chengyong He, Chonggang Wang, Yulin Zhou, Jian Li, Zhenghong Zuo *. Embryonic exposure to benzo(a)pyrene influences neural development and function in rockfish (Sebastiscus marmoratus). Neurotoxicology. 2012; 33:758-762.

41. Chengyong He, Chonggang Wang, Bowen Li, Fazhi Xie, Yixin Chen, Zhenghong Zuo *. Tissue-specific and embryonic expression of the retinoid X receptors in Sebastiscus marmoratus. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2009; 154(2):221-228.