研究领域：

主要从事阿尔茨海默病等神经系统疾病的发病机制研究，已在SCI期刊发表学术论文40余篇，累计被引用2000余次；获得发明专利授权2项；参编教材3部；荣获福建省自然科学奖二等奖、厦门大学教学成果二等奖等荣誉。

学习经历：

2000~2004  厦门大学生命科学学院生命科学专业  理学学士

2004~2009  厦门大学生命科学学院细胞生物学专业    理学博士

工作经历：

2005~2006  美国Sanford-Burnham医学研究所   访问学者

2008~2008  美国Sanford-Burnham医学研究所   访问学者

2009~2011  厦门大学生物医学研究院   助理教授

2011~2024  厦门大学医学院   助理教授

2024~至今 厦门大学医学院    副教授

代表性成果：

1. Wang Z, Niu M, Zheng N, Meng J, Jiang Y, Yang D, Yao P, Yao T, Luo H, Xu H, Ge Y, Zhang YW, Zhang X*. Increased level of RAB39B leads to neuronal dysfunction and behavioural changes in mice. J Cell Mol Med, 2023, 27(9):1214-1226.

2. Wang Z, Yang D, Jiang Y, Wang Y, Niu M, Wang C, Luo H, Xu H, Li J, Zhang YW, Zhang X*. Loss of RAB39B does not alter MPTP-induced Parkinson’s disease-like phenotypes in mice. Front Aging Neurosci, 2023, 15:1087823.

3. Peng A, Gao Y, Zhuang X, Lin Y, He W, Wang Y, Chen W, Chen T, Huang X, Yang R, Huang Y*, Xi S*, Zhang X*. Bazhu Decoction, a Traditional Chinese Medical Formula, Ameliorates Cognitive Deficits in the 5xFAD Mouse Model of Alzheimer’s Disease. Front Pharmacol. 2019, 10:1391.

4. Xie Y, Niu M, Ji C, Huang TY, Zhang C, Tian Y, Shi Z, Wang C, Zhao Y, Luo H, Can D, Xu H, Zhang YW*, Zhang X*. SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse. Front Cell Neurosci. 2019, 13:410.

5.Zhang C, Tan Z, Xie Y, Zhao Y, Huang TY, Lu Z, Luo H, Can D, Xu H, Zhang YW*, Zhang X*. Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway. Front Aging Neurosci. 2019, 11:243.

6. Zhang X, Huang TY, Yancey J, Luo H, Zhang YW*. Role of Rab GTPases in Alzheimer's Disease. ACS Chem Neurosci. 2019, 10(2):828-838.

7. Zhang X, Li Y, Xu H, Zhang YW*. The γ-secretase complex: from structure to function. Front Cell Neurosci. 2014,8:427

8. Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H*, Zhang YW*. Hypoxia inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and β-amyloid generation. J Biol Chem. 2007, 282(15):10873-10880.

承担过的重要课题：

1. 国家自然科学基金面上项目，82371420，2024-01至2027-12，主持

2. 福建省自然科学基金面上项目，2023J01113331，2023-08至 2026-08，主持

3. 福建省自然科学基金面上项目，2023J011604，2023-08至2026-08，共同承担

4. 厦门市自然科学基金面上项目，3502Z202373012，2023-07至2026-06，主持

5. 国家自然科学基金青年科学基金项目，81000540，2011-01至2013-12，主持

6. 福建省自然科学基金面上项目，2010J0101，2010-06至2013-05，主持

所有论文列表：

1. Zheng N, Li K, Cao J, Wang Z, Zhang L, Zhao Z, He J, Wang Y, Zhu X, Chen Y, Meng J, Zhao D, Niu M, Luo H, Zhang X, Sun H, Zhang YW*. Electrophysiology-based screening identifies neuronal HtrA serine peptidase 2 (HTRA2) as a synaptic plasticity regulator participating in tauopathy. Transl Psychiatry. 2025, 15(1):5.

2. Hu B, Zhou Y, Wu C, Xiao N, Li J, Li X, Li Y, Zhang X, Huang X, Song Y, Wang Z, Zhang YW*, Zhang Z*, Zheng H*. Evaluation of Soluble Colony Stimulating Factor 1 Receptor (CSF1R) in Peripheral Blood as a Diagnostic Marker of CSF1R-Related Disorder (CSF1R-RD) in a Murine Model and CSF1R-RD Patients. Ann Neurol. 2025, 97(2):397-403.

3. Meng J*, Han L, Xu H, Zhang L, Liu Z, Zhou Y, Zhang X, Luo H, Zhang YW*. TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance. Int Immunopharmacol. 2024, 127:111445.

4. Zhang H, Zheng Q, Guo T, Zhang S, Zheng S, Wang R, Deng Q, Yang G, Zhang S, Tang L, Qi Q, Zhu L, Zhang XF, Luo H, Zhang X, Sun H, Gao Y, Zhang H, Zhou Y, Han A, Zhang CS, Xu H, Wang X*. Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability. Mol Psychiatry. 2024, 29(6):1569-1582.

5. Zhao S, Jiang X, Han L, Jiang Y, Wang Y, Meng J, Zhu X, Zhang X, Luo H, Zhang YW*. Tau reduction attenuates autism-like features in Fmr1 knockout mice. Mol Autism. 2023, 14(1):42.

6. Wang T, Zhou YQ, Wang Y, Zhang L, Zhu X, Wang XY, Wang JH, Han LK, Meng J, Zhang X, Luo H, Ma QL, Wang ZX, Zhang YW*. Long-term potentiation-based screening identifies neuronal PYGM as a synaptic plasticity regulator participating in Alzheimer's disease. Zool Res. 2023, 44(5):867-881.

7. Zhao Y, Zheng Q, Hong Y, Gao Y, Hu J, Lang M, Zhang H, Zhou Y, Luo H, Zhang X, Sun H, Yan XX, Huang TY, Wang YJ, Xu H, Liu C, Wang X*. β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice. Nat Neurosci. 2023, 26(7):1170-1184.

8. Li X, Hu B, Guan X, Wang Z, Zhou Y, Sun H, Zhang X, Li Y, Huang X, Zhao Y, Wang X, Xu H, Zhang YW, Wang Z*, Zheng H*. Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). J Neuroinflammation, 2023, 20(1):134.

9. Wang Z, Niu M, Zheng N, Meng J, Jiang Y, Yang D, Yao P, Yao T, Luo H, Xu H, Ge Y, Zhang YW, Zhang X*. Increased level of RAB39B leads to neuronal dysfunction and behavioural changes in mice. J Cell Mol Med, 2023, 27(9):1214-1226.

10. Gao Y, Hong Y, Huang L, Zheng S, Zhang H, Wang S, Yao Y, Zhao Y, Zhu L, Xu Q, Chai X, Zeng Y, Zeng Y, Zheng L, Zhou Y, Luo H, Zhang X, Zhang H, Zhou Y, Fu G, Sun H, Huang TY, Zheng Q, Xu H, Wang X*. β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function. Cell, 2023, 186(5):1026-1038.e20.

11. Wang Z, Yang D, Jiang Y, Wang Y, Niu M, Wang C, Luo H, Xu H, Li J, Zhang YW, Zhang X*. Loss of RAB39B does not alter MPTP-induced Parkinson’s disease-like phenotypes in mice. Front Aging Neurosci, 2023, 15:1087823.

12. Jiang Y, Han L, Meng J, Wang Z, Zhou Y, Yuan H, Xu H, Zhang X, Zhao Y, Lu J, Xu H, Zhang C, Zhang YW*. Gene therapy using human FMRP isoforms driven by the human FMR1 promoter rescues fragile X syndrome mouse deficits. Mol Ther Methods Clin Dev, 2022, 27:246-258.

13. Liu FR, Zhou Y, Wang Y, Huang LL, Zhang X, Luo H, Wu SY, Lyu HY, Huang LH, Xu H, Zhang YW*. Pedigree-based study to identify GOLGB1 as a risk gene for bipolar disorder. Transl Psychiatry, 2022, 12(1):390.

14. Wang C*, Zhang Y, Zhao D, Huo Y, Xie J, Zhang X, Luo H, Xu H, Zhang YW*. Phenazopyridine promotes RPS23RG1/Rps23rg1 transcription and ameliorates Alzheimer-associated phenotypes in mice. Neuropsychopharmacology, 2022, 47(12):2042-2050.

15. Meng J, Han L, Zheng N, Wang T, Xu H, Jiang Y, Wang Z, Liu Z, Zheng Q, Zhang X, Luo H, Can D, Lu J, Xu H, Zhang YW*. Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice. J Neurosci, 2022, 42(25):4958-4979.

16. Zheng Q, Song B, Li G, Cai F, Wu M, Zhao Y, Jiang L, Guo T, Shen M, Hou H, Zhou Y, Zhao Y, Di A, Zhang L, Zeng F, Zhang XF, Luo H, Zhang X, Zhang H, Zeng Z, Huang TY, Dong C, Qing H, Zhang Y, Zhang Q, Wang X, Wu Y, Xu H*, Song W*, Wang X*. USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Abeta generation. J Clin Invest, 2022,132(5):e152170.

17. Hu B, Duan S, Wang Z, Li X, Zhou Y, Zhang X, Zhang YW *, Xu H*, Zheng H*. Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders. Front. Aging Neurosci, 2021, 13:789834.

18. Zhang M, Zhou Y, Lu Z, Xiao X, Jiang Y, Ning J, Zhang X, Luo H, Can D, Lu J, Xu H, Zhang YW*. Profiling of Sexually Dimorphic Genes in Neural Cells to Identify Eif2s3y, Whose Overexpression Causes Autism-Like Behaviors in Male Mice. Front Cell Dev Biol, 2021, 9:669798.

19. Zhang H, Hong Y, Yang W, Wang R, Yao T, Wang J, Liu K, Yuan H, Xu C, Zhou Y, Li G, Zhang L, Luo H, Zhang X, Du D, Sun H, Zheng Q, Zhang YW, Zhao Y, Zhou Y, Xu H, Wang X*. SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate. Natl Sci Rev, 2021, nwab024.

20. Huo Y, Gao Y, Zheng Q, Zhao D, Guo T, Zhang S, Zeng Y, Cheng Y, Gu H, Zhang L, Zhu B, Luo H, Zhang X, Zhou Y, Zhang Y, Sun H, Xu H, Wang X*. Overexpression of Human SNX27 Enhances Learning and Memory Through Modulating Synaptic Plasticity in Mice. Front Cell Dev Biol. 2020, 8:595357.

21. Meng J, Han L, Zheng N, Xu H, Liu Z, Zhang X, Luo H, Can D, Sun H, Xu H, Zhang YW*. TMEM59 Haploinsufficiency Ameliorates the Pathology and Cognitive Impairment in the 5xFAD Mouse Model of Alzheimer’s Disease. Front Cell Dev Biol. 2020, 8:596030.

22. Zhao D, Zhou Y, Huo Y, Meng J, Xiao X, Han L, Zhang X, Luo H, Can D, Sun H, Huang TY, Wang X, Zhang J, Liu FR, Xu H, Zhang YW*. RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation. Cell Death Differ. 2020, 28(1):337-348.

23. Liu Z, Ning J, Zheng X, Meng J, Han L, Zheng H, Zhong L, Chen XF, Zhang X, Luo H, Can D, Xu H, Zhang YW*. TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities. Cell Death Dis. 2020, 13;11(8):678.

24. Ye X, Tian W, Wang G, Zhang X, Zhou M, Zeng D, Liu X, Yao X*, Zhang Y*, Chen H*. Phenolic Glycosides from the Roots of Ficus hirta Vahl. and Their Antineuroinflammatory Activities. J Agric Food Chem. 2020, 68(14):4196-4204.

25. Zeng F, Ma X, Zhu L, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, and Wang X*. The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability. PLoS Biol. 2019, 17(12):e3000525.

26. Peng A, Gao Y, Zhuang X, Lin Y, He W, Wang Y, Chen W, Chen T, Huang X, Yang R, Huang Y*, Xi S*, Zhang X*. Bazhu Decoction, a Traditional Chinese Medical Formula, Ameliorates Cognitive Deficits in the 5xFAD Mouse Model of Alzheimer’s Disease. Front Pharmacol. 2019, 10:1391.

27. Zhang H, Zhu L, Wang F, Wang R, Hong Y, Chen Y, Zhu B, Gao Y, Luo H, Zhang X, Sun H, Zhou Y, Yao Y and Wang X*. Novel KCNJ10 Compound Heterozygous Mutations Causing EAST/SeSAMELike Syndrome Compromise Potassium Channel Function. Front Genet. 2019, 10:912.

28. Xie Y, Niu M, Ji C, Huang TY, Zhang C, Tian Y, Shi Z, Wang C, Zhao Y, Luo H, Can D, Xu H, Zhang YW*, Zhang X*. SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse. Front Cell Neurosci. 2019, 13:410.

29. Zhang C, Tan Z, Xie Y, Zhao Y, Huang TY, Lu Z, Luo H, Can D, Xu H, Zhang YW, Zhang X*. Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway. Front Aging Neurosci. 2019, 11:243.

30. Zhao S, Li Z, Zhang M, Zhang L, Zheng H, Ning J, Wang Y, Wang F, Zhang X, Gan H, Wang Y, Zhang X, Luo L, Bu G, Xu H, Yao Y*, Zhang YW*. A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II. Exp Mol Med, 2019, 51(7):84.

31. Zhang X, Huang TY, Yancey J, Luo H, Zhang Y*. Role of Rab GTPases in Alzheimer's Disease. ACS Chem Neurosci. 2019, 10(2):828-838.

32. Zhao D, Meng J, Zhao Y, Huo Y, Liu Y, Zheng N, Zhang M, Gao Y, Chen Z, Sun H, Wang X, Jing C, Zhang T, Zhang X, Luo H, Wang X, Zhang J, Liu F-r, Li Y, Bu G, Wen L, Huang TY, Xu H, Zhang YW*. RPS23RG1 is Required for Synaptic Integrity and Rescues Alzheimer’s Associated Cognitive Deficits. Biol Psychiat. 2019, 86(3):171-184.

33. Zhang H, Huang T, Hong Y, Yang W, Zhang X, Luo H, Xu H, Wang X*. The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases. Front Aging Neurosci. 2018, 10:79.

34. Wang X*, Zhou Y, Wang J, Tseng IC, Huang T, Zhao Y, Zheng Q, Gao Y, Luo H, Zhang X, Bu G, Hong W, Xu H*. SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis. J Neurosci. 2016,36(50): 12586-12597.

35. Zhang X, Li Y, Xu H, Zhang YW*. The γ-secretase complex: from structure to function. Front Cell Neurosci. 2014,8:427.

36. Jiang S, Li Y, Zhang X, Bu G, Xu H, Zhang YW*. Trafficking regulation of proteins in Alzheimer's disease. Mol Neurodegener. 2014, 9:6.

37. Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JD, Bu G, Reed JC, Liao FF, Chen YG*, Xu H*. Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration. J Neurosci. 2012, 32(44):15565-15576.

38. Jiang S, Wang Y, Ma Q, Hou H, Zhang X, Zhang YW*. M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation. Neurosci Lett. 2012, 515(2):125-130.

39. Zhao Y, Wang Y, Yang J, Wang X, Zhao Y, Zhang X, Zhang YW*. Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing. Mol Neurodegener. 2012, 7:30.

40. Zhao Y, Wang Y, Hu J, Zhang X, Zhang YW*. CutA divalent cation tolerance homolog (E. coli) (CUTA) regulates β-cleavage of β-amyloid precursor protein (APP) through interacting with β-Site APP cleaving protein 1 (BACE1). J Biol Chem. 2012, 287(14):11141-11150.

41. Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H*, Zhang YW*. Hypoxia inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and β-amyloid generation. J Biol Chem, 2007, 282(15):10873-10880.

42. Wang R, Zhang YW, Zhang X, Liu R, Zhang X, Hong SH, Xia K, Xia J, Zhang Z*, Xu H*. Transcriptional regulation of APH-1A and increased γ-secretase cleavage of APP and Notch by HIF-1 and hypoxia. FASEB J, 2006, 20(8):1275-1277.

43. Wang R, Zhang YW, Sun P, Liu R, Zhang X, Zhang X, Xi JH, Xu H*, Zhang Z*. Transcriptional regulation of PEN-2, a key component of the γ-secretase complex, by CREB. Mol Cell Biol, 2006, 26(4):1347-1354.