陶荣坤
副教授,博士生导师 研究方向:开发在体单细胞动态示踪、光控技术及创新基因治疗系统 邮 箱:taorongkun@xmu.edu.cn
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研究领域
本课题组致力于开发新型精准的遗传编码光学工具,推动“系统、定量、在体、动态”的细胞生物学研究新范式,在Nature Methods、Cell Discovery、Nature Communications等期刊发表系列研究论文。课题组综合利用遗传编码荧光探针、光遗传学及基因编辑技术,以斑马鱼和小鼠为研究对象,系统解析在体单细胞的动态变化及其在生理功能和疾病发生发展中的作用,并探索新型基因治疗策略。主要研究方向:
1.细胞动态示踪:开发遗传编码荧光探针,在体实时追踪细胞动态,解析其生理和病理作用。
2.单细胞精准操控:开发光遗传学技术,在体精确调控基因表达、蛋白活性和细胞行为。
3.高效转基因技术:设计“一步法”转基因系统,快速建立转基因和遗传病动物模型。
4.基因治疗:研发新型基因递送工具,探索杜氏肌营养不良等罕见病的创新治疗策略。
学习经历
2013~2017 华东理工大学生物化学与分子生物学专业 理学博士
2010~2013 华东理工大学生物工程专业 硕士研究生
2006~2010 华东理工大学生物技术专业 理学学士
工作经历
2025~至今 厦门大学医学院 副教授
2020~2025 中国科学院脑科学与智能技术卓越创新中心 副研究员
2018~2018 霍华德•休斯医学研究所珍妮莉亚研究校区 访问学者
2018~2020 加州大学洛杉矶分校(UCLA) 博士后
代表性成果
1.Rongkun Tao*, Yuzheng Zhao*, Huanyu Chu*, Aoxue Wang, Jiahuan Zhu, Xianjun Chen, Yejun Zou, Mei shi, Renmei Liu, Ni Su, Jiulin Du, Hai-Meng Zhou, Linyong Zhu, Xuhong Qian, Haiyan Liu, Joseph Loscalzo, Yi Yang, Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism. Nature Methods. 2017, 14(7):720-728.
2.Rongkun Tao*, Kui Wang*, Tian-lun Chen*, Xin-xin Zhang, Jian-bin Cao, Wen-quan Zhao, Jiu-lin Du, Yu Mu, A genetically encoded ratiometric indicator for tryptophan. Cell discovery. 2023.9(206).
3.Kui Wang*, Tian-lun Chen*, Xin-xin Zhang*, Jian-bin Cao*, Pengcheng Wang, Mingcang Wang, Jiu-lin Du#, Yu Mu#, Rongkun Tao#, Unveiling tryptophan dynamics and functions across model organisms via quantitative imaging. BMC biology. 2024,258(22)
4.Peng-Cheng Wang, Hao Deng, Rang Xu#, Jiu-Lin Du#, Rongkun Tao#, Improvement in Tol2 transposon for efficient large-cargo capacity transgene applications in cultured cells and zebrafish (Danio rerio). Zoological Research. 2024.45(3):567-574.
5.Rongkun Tao*, Mei Shi*, Yejun Zou*, Di Cheng, Qiaohui Wang, Renmei Liu, Aoxue Wang, Jiahuan Zhu, Lei Deng, Hanyang Hu, Xianjun Chen, Jiulin Du, Weiping Zhu, Yuzheng Zhao, Yi Yang, Multicoloured fluorescent indicators for live-cell and in vivo imaging of inorganic mercury dynamics. Free Radical Biology & Medicine. 2018, 121:26-37.
承担的重要课题
1.国家自然科学基金面上项目,32171090,2022-1至2025-12,主持;
2.科技部科技创新2030—“脑科学与类脑研究”重大项目,2021ZD0202203,2021-12至2026-11,骨干;
3.上海市自然科学基金原创探索类项目,21ZR1482600,2021-07至2024-06,主持。
获奖及荣誉
1.厦门大学南强青年拔尖B类人才,2025年;
2.中国科学院脑科学与智能技术卓越创新中心所级特聘骨干,2024;
3.中国科学院青年促进会会员,2023年。
所有论文列表
1.Kui Wang*, Tian-lun Chen*, Xin-xin Zhang*, Jian-bin Cao*, Pengcheng Wang, Mingcang Wang, Jiu-lin Du#, Yu Mu#, Rongkun Tao#, Unveiling tryptophan dynamics and functions across model organisms via quantitative imaging. BMC biology. 2024,258(22)
2.Peng-Cheng Wang, Hao Deng, Rang Xu#, Jiu-Lin Du#, Rongkun Tao#, Improvement in Tol2 transposon for efficient large-cargo capacity transgene applications in cultured cells and zebrafish (Danio rerio). Zoological Research. 2024.45(3):567-574.
3.Rongkun Tao*, Kui Wang*, Tian-lun Chen*, Xin-xin Zhang, Jian-bin Cao, Wen-quan Zhao, Jiu-lin Du, Yu Mu, A genetically encoded ratiometric indicator for tryptophan. Cell discovery. 2023.9(206).
4.Rongkun Tao*, Mei Shi*, Yejun Zou*, Di Cheng, Qiaohui Wang, Renmei Liu, Aoxue Wang, Jiahuan Zhu, Lei Deng, Hanyang Hu, Xianjun Chen, Jiulin Du, Weiping Zhu, Yuzheng Zhao, Yi Yang, Multicoloured fluorescent indicators for live-cell and in vivo imaging of inorganic mercury dynamics. Free Radical Biology & Medicine. 2018, 121:26-37.
5.Rongkun Tao*, Yuzheng Zhao*, Huanyu Chu*, Aoxue Wang, Jiahuan Zhu, Xianjun Chen, Yejun Zou, Mei shi, Renmei Liu, Ni Su, Jiulin Du, Hai-Meng Zhou, Linyong Zhu, Xuhong Qian, Haiyan Liu, Joseph Loscalzo, Yi Yang, Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism. Nature Methods. 2017, 14(7):720-728.
6.Mark A Lobas, Rongkun Tao, Jun Nagai, Mira T Kronschläger, Philip M Borden, Jonathan S Marvin, Loren L Looger, Baljit S Khakh, A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP. Nature Communications. 2019, 10(1):711.
7.Hanyang Hu, Yanfang Gu, Lei Xu, Yejun Zou, Aoxue Wang, Rongkun Tao, Xianjun Chen, Yuzheng Zhao & Yi Yang, A genetically encoded toolkit for tracking live-cell histidine dynamics in space and time. Scientific Reports. 2017, 7:43479.