研究领域

本课题组重点关注子宫内膜发育、周期性重塑和妊娠期蜕膜化的生理病理机制。利用转基因、组织特异性基因敲除小鼠模型和体外子宫细胞、类器官培养，结合多组学分析和生化分子技术，致力于：1）阐明子宫各类细胞命运决定和发育的分子调控机制；2）揭示子宫内膜周期性重塑和妊娠期蜕膜化的时空图谱和信号网络。近期在Nature Communications、Cell Reports、Cell Death & Differentiation等国际学术期刊上发表系列研究论文。

学习经历

2015~2022，中国科学院动物研究所发育生物学专业，理学博士

2011~2015，中国农业大学生物科学专业，理学学士

工作经历

2024~至今，厦门大学医学院，助理教授

2022~2024，厦门大学医学院，博士后

代表性成果

1. Bao H^#, Sun Y^#, Deng N^#, Zhang L, Jia Y, Li G, Gao Y, Li X, Tang Y, Cai H, Lu J, Wang H^*, Deng W^*, Kong S^*. PR-SET7 epigenetically restrains uterine interferon response and cell death governing proper postnatal stromal development. 2024, Nat Commun, 15(1):4920.

2. Yang N^#, Sun Y^#, Han B, Deng N, Li G, Han Q, Wang Y, Cai H, Liu F, Cao B, Deng W, Bao H^*, Kong S^*, Lu J^*, Wang H^*. Trophoblastic signals facilitate endometrial interferon response and lipid metabolism, ensuring normal decidualization. 2024, Cell Rep, 43(6):114246.

3. Deng N^#, Li G^#, Zhang L, Wang P, Liu M, He B, Tang Y, Cai H, Lu J, Wang H^*, Deng W^*, Bao H^*, Kong S^*. H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation. 2024, Cell Death Differ, 31(8):1013-1028.

4. Bao H^#, Wang H^*. Basic research advances in China on embryo implantation, placentation, and parturition. 2024, Meternal-Fetal Medicine. 6(1):37-49.

5. Zhao H^#, Wang Y^#, Xu H^#, Liu M, Xu X, Zhu S, Liu Z, Cai H, Wang Y, Lu J, Yang X, Kong S, Bao H^*, Wang H^*, Deng W^*. Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution. 2023, iScience, 26(10):107796.

6. Bao H^#, Sun Y, Yang N, Deng N, Ni Z, Tang Y, Li G, Du L, Wang YL, Chen D^*, Wang H^*, Kong S^*. Uterine Notch2 facilitates pregnancy recognition and corpus luteum maintenance via upregulating decidual Prl8a2. 2021, PLoS Genet, 17(8):e1009786.

7. Bao H^#, Liu D^#, Xu Y, Sun Y, Mu C, Yu Y, Wang C, Han Q, Liu S, Cai H, Liu F, Kong S, Deng W, Cao B, Wang H^*, Wang Q^*, Lu J^*. Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2. 2020, BMC Biol, 18(1):151.

8. Zhou C^#, Bao H^#, Kong S, Lu J, Wang H^*. Developmental aspect of decidual patterning. 2017, Reprod Dev Med, 1(2):100-114.

承担的重要课题

1. 国家自然科学基金委员会，青年科学基金项目，82301886，RNA结合蛋白HuR在子宫内膜蜕膜化中的作用及机制，2024.01-2026.12，在研，主持。

所有论文列表

1. Bao H, Sun Y, Deng N, Zhang L, Jia Y, Li G, Gao Y, Li X, Tang Y, Cai H, Lu J, Wang H, Deng W, Kong S. PR-SET7 epigenetically restrains uterine interferon response and cell death governing proper postnatal stromal development. 2024, Nat Commun, 15(1):4920.

2. Yang N, Sun Y, Han B, Deng N, Li G, Han Q, Wang Y, Cai H, Liu F, Cao B, Deng W, Bao H, Kong S, Lu J, Wang H. Trophoblastic signals facilitate endometrial interferon response and lipid metabolism, ensuring normal decidualization. 2024, Cell Rep, 43(6):114246.

3. Deng N, Li G, Zhang L, Wang P, Liu M, He B, Tang Y, Cai H, Lu J, Wang H, Deng W, Bao H, Kong S. H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation. 2024, Cell Death Differ, 31(8):1013-1028.

4. Bao H, Wang H. Basic research advances in China on embryo implantation, placentation, and parturition. 2024, Meternal-Fetal Medicine. 6(1):37-49.

5. Zhao H, Wang Y, Xu H, Liu M, Xu X, Zhu S, Liu Z, Cai H, Wang Y, Lu J, Yang X, Kong S, Bao H, Wang H, Deng W. Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution. 2023, iScience, 26(10):107796.

6. Bao H, Sun Y, Yang N, Deng N, Ni Z, Tang Y, Li G, Du L, Wang YL, Chen D, Wang H, Kong S. Uterine Notch2 facilitates pregnancy recognition and corpus luteum maintenance via upregulating decidual Prl8a2. 2021, PLoS Genet, 17(8):e1009786.

7. Bao H, Liu D, Xu Y, Sun Y, Mu C, Yu Y, Wang C, Han Q, Liu S, Cai H, Liu F, Kong S, Deng W, Cao B, Wang H, Wang Q, Lu J. Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2. 2020, BMC Biol, 18(1):151.

8. Zhou C, Bao H, Kong S, Lu J, Wang H. Developmental aspect of decidual patterning. 2017, Reprod Dev Med, 1(2):100-114.

9. Wang P, Du S, Guo C, Ni Z, Huang Z, Deng N, Bao H, Deng W, Lu J, Kong S, Zhang H, Wang H. The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity. 2024, Autophagy, 20(1):58-75.

10. Liu M, Ji M, Cheng J, Li Y, Tian Y, Zhao H, Wang Y, Zhu S, Zhang L, Xu X, Feng GS, Liang X, Bao H, Tang Y, Kong S, Lu J, Wang H, Lu Z, Deng W. Deciphering a critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution. 2023, Nat Commun, 14(1):7356.

11. Tang Y, Qiu J, Tang Z, Li G, Gu M, Wang Y, Bao H, Deng W, Lu Z, Otsu K, Wang Z, Wang H, Kong S. P38α MAPK is a gatekeeper of uterine progesterone responsiveness at peri-implantation via Ube3c-mediated PGR degradation. 2022, PNAS, 119(32):e2206000119.

12. Huang P, Deng W, Bao H, Lin Z, Liu M, Wu J, Zhou X, Qiao M, Yang Y, Cai H, Rao F, Chen J, Chen D, Lu J, Wang H, Qin A, Kong S. SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization. 2022, Elife, 11:e72073.

13. Liu M, Deng W, Tang L, Liu M, Bao H, Guo C, Zhang C, Lu J, Wang H, Lu Z, Kong S. Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling. 2022, Nat Commun, 13(1):1006.

14. Zhou C, Lv M, Wang P, Guo C, Ni Z, Bao H, Tang Y, Cai H, Lu J, Deng W, Yang X, Xia G, Wang H, Wang C, Kong S. Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation. 2021, J Mol Cell Biol, 13(9):646-661.

15. Kong S, Zhou C, Bao H, Ni Z, Liu M, He B, Huang L, Sun Y, Wang H, Lu J. Epigenetic control of embryo-uterine crosstalk at peri-implantation. 2019, Cell Mol Life Sci, 76(24):4813-4828.

16. Huang L, Wang L, Bao H, Xu Y, Meng M, Qiao M, Wang H, Kong S. Traditional Chinese medicine Dingkun Pill facilitates uterine receptivity for implantation in mice. 2019, Biol Reprod, 101(4):695-703.

17. Zhang Y, Meng N, Bao H, Jiang Y, Yang N, Wu K, Wu J, Wang H, Kong S, Zhang Y. Circadian gene PER1 senses progesterone signal during human endometrial decidualization. 2019, J Endocrinol, 243(3):229-242.

18. Xin Q, Kong S, Yan J, Qiu J, He B, Zhou C, Ni Z, Bao H, Huang L, Lu J, Xia G, Liu X, Chen ZJ, Wang C, Wang H. Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation. 2018, J Clin Invest, 128(1):175-189.

19. Cui T, He B, Kong S, Zhou C, Zhang H, Ni Z, Bao H, Qiu J, Xin Q, Reinberg D, Lydon JP, Lu J, Wang H. PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice. 2017, Cell Death Differ, 24(12):2013-2021.

20. Tu Z, Wang Q, Cui T, Wang J, Ran H, Bao H, Lu J, Wang B, Lydon JP, DeMayo F, Zhang S, Kong S, Wu X, Wang H. Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. 2016, Cell Death Differ, 23(1):169-81.