王乐韵 厦门大学教授，博士生导师 国家优秀青年科学基金获得者 研究方向：哺乳动物器官发育机制与制造 所在医院：厦门大学附属心血管病医院 办公电话：0592-2291939 邮    箱：wangleyun@xmu.edu.cn

研究领域

课题组立足临床需求，系统开展哺乳动物器官发育调控机制解析与体内外器官构建研究。研究以发育生物学为理论核心，融合表观遗传调控、基因编辑、干细胞生物学及生物工程等交叉技术，聚焦重要器官发育规律、疾病致病机制与组织再生重建的关键科学问题，致力于构建从基础机制解析到临床转化应用的完整研究体系。重点围绕心脏等重要器官，系统研究器官发育过程中的细胞命运决定、形态建成、功能成熟及其调控网络；解析发育异常与器官疾病发生的分子基础，开发相应干预与治疗策略；探索器官体外构建及异种器官构建的新策略；推动相关研究向疾病模型构建、药物开发、再生医学与器官替代治疗转化。相关研究成果以通讯作者或第一作者(含共同)发表于 Cell、Science、Nature Genetics、Cell Stem Cell 等期刊。

主要研究方向

1.重要器官发育、形态建成与功能成熟的分子调控机制及表观遗传网络；

2.器官发育异常及相关疾病发生机制解析与干预策略开发；

3.体外胚胎培养、体外类器官构建与异种器官制备关键技术研发及转化应用。

学习经历

2013~2017 东北农业大学  发育生物学             理学博士；

2009~2013 东北农业大学  生物科学（理科基地班）  理学学士。

工作经历

2023~至今 厦门大学医学院             教授；

2023~至今 厦门大学附属心血管病医院  研究员；

2017~2023 干细胞与再生医学创新研究院 特别研究助理；

2017~2023 中国科学院动物研究所       博士后。

代表性成果(^#：第一作者；*：通讯作者)

1.Wang LY^#, Li ZK^#, Wang LB^#, Liu C^#, Sun XH^#, Feng GH^#, Wang JQ, Li YF, Qiao LY, Nie H, Jiang LY, Sun H, Xie YL, Ma SN, Wan HF, Lu FL*, Li W*, Zhou Q*. Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer. Cell Stem Cell. 2020;27(2):315-325.

2.Wang J^#, Wang L^#, Feng G^#, Wang Y^#, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W*, Zhou Q*. Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos. Cell. 2018;175(7):1887-1901.

3.Li ZK^#*, Wang LB^#, Wang LY^#, Sun XH^#, Ren ZH^#, Ma SN^#, Zhao YL^#, Liu C, Feng GH, Liu T, Pan TS, Shan QT, Xu K, Luo GZ*, Zhou Q*, Li W*. Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals. Cell Stem Cell. 2025;32(3):361-374.

4.Wang J^#*, Zhang Y^#, Gao J^#, Feng G, Liu C, Li X, Li P, Liu Z, Lu F, Wang L*, Li W*, Zhou Q*, Liu Y*. Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos. Nat Struct Mol Biol. 2024;31(9):1341-1354.

5.Wang LB^#, Li ZK^#, Wang LY^#, Xu K^#, Ji TT^#, Mao YH, Ma SN, Liu T, Tu CF, Zhao Q, Fan XN, Liu C, Wang LY, Shu YJ, Yang N*, Zhou Q*, Li W*. A sustainable mouse karyotype created by programmed chromosome fusion. Science. 2022;377(6609):967-975.

6.Xu Q^#, Xiang Y^#, Wang Q^#, Wang L^#, Brind'Amour J, Bogutz AB, Zhang Y, Zhang B, Yu G, Xia W, Du Z, Huang C, Ma J, Zheng H, Li Y, Liu C, Walker CL, Jonasch E, Lefebvre L, Wu M, Lorincz MC, Li W*, Li L*, Xie W*. SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development. Nat Genet. 2019;51(5):844-856

7.Li ZK^#, Wang LY^#, Wang LB^#, Feng GH^#, Yuan XW^#, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W*, Zhou Q*, Hu BY*. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell. 2018;23(5):665-676（

8.Guo R^#, Sun X^#, Wang F^#, Han D^#, Yang Q, Gao H, Li Z, Shao Z, Shi J, Yang R, Huo X, Yan J, Li G, Xiao Q, Liu Y, Zhang S, Liu X, Zhou Y, Wang L*, Hu C*, Xu C*. Engineered IscB-ωRNA system with improved base editing efficiency for disease correction via single AAV delivery in mice. Cell Reports. 2024;43(11):114973

9.Li J^#, Zhang Y^#, Huang Y^#, Li R, Wang K, Guo D, Huang Z, Yao Y, Xue Y, Sun G, Jiang C, Wang L*, Li C*, Zhao Q*. Three-Dimensional Curved Workflow-Based Optical Coherence Tomography Angiography for Enhancing Atopic Dermatitis Theranostics. Research (Wash D C). 2025;8:0778.

10.Wang L^#, Teng F^#, Yuan X^#, Liu C^#, Wang J, Li Y, Cui T, Li T, Liu Z*, Zhou Q*. Overexpression of Stella improves the efficiency of nuclear transfer reprogramming. J Genet Genomics. 2017;44(7):363-366.

承担的重要研究项目

1.国家自然科学基金优秀青年项目，2025-1至2027-12，主持

2.国家自然科学基金面上项目，2024-1至2027-12，主持

3.国家重点研发计划项目，2024-12至2027-11，骨干

4.厦门市卫健委重大科研专项，2025-1至2028-12，主持

5.福建省高层次人才，2023-12至2026-12，主持

6.河北省战略性技术专项，2023-12至2026-11，骨干

7.厦门市重大科技计划项目，2020-1至2025-12，主持

8.国家自然科学基金面上项目，2020-1至2022-12，主持。

9.博士后创新人才支持计划，2017-7至2019-12，主持

获奖及荣誉

1.厦门市先进工作者，2025年；

2.福建省科学技术进步奖二等奖，2025年；

3.国家自然科学基金优秀青年基金，2024年；

4.中国动物学会“青年科技奖”，2023年；

5.中国生命科学领域十大进展，2022年；

6.麻省理工35岁以下科技创新35人，2021年；

7.福布斯30岁以下科技创新30人封面，2020年；

8.中国生命科学领域十大进展，2019年；

所有论文列表(^#：第一作者；*：通讯作者)

1.Guo J^#, Lyu J^#, Gao Z^#, Jia T^#, Wang L^#, Dong J, Gu Z, Ji S, Li W, Wang H, Zhai J*, Yu L*, Feng G*, Zhou Q*, Gu Q*. 3D biomimetic niche modulates embryo development in vitro. Nat Commun. 2026;17(1):1279.

2.Chang T^#, Zheng Y^#, Jiang M^#, Jia S, Bai J, Zheng Z, Li S, Guo J, Wang Y, Wang Y, Liu H, Liu J, Ni L, Cheng X, Liu S, Zhang H, Pi W, Lin F, Liu S, Wang W, Wang G, Wang L, Miao L, Lu X, Deng Z, Bai B, Qin Z, Gao H*, Shao Y*. Peptide codes for organ-selective mRNA delivery. Nature Materials. 2026;25(1):146-159.

3.Li J^#, Zhang Y^#, Huang Y^#, Li R, Wang K, Guo D, Huang Z, Yao Y, Xue Y, Sun G, Jiang C, Wang L*, Li C*, Zhao Q*. Three-Dimensional Curved Workflow-Based Optical Coherence Tomography Angiography for Enhancing Atopic Dermatitis Theranostics. Research (Wash D C). 2025;8:0778.

4.Li X^#, Lin F^#, Cui Q^#, Sun S, Li S, Wang Y, Wang Y, Bai J, Liu S, Guo J, Han Y, Zhang M, Chang T, Zheng Y, Liu J, Liu L, Wang L, Fu J, Liu X*, Bai B*, Shao Y*. Human gastroids to model regional patterning in early stomach development. Nature. 2025;646(8086):893-902.

5.Li ZK^#*, Wang LB^#, Wang LY^#, Sun XH^#, Ren ZH^#, Ma SN^#, Zhao YL^#, Liu C, Feng GH, Liu T, Pan TS, Shan QT, Xu K, Luo GZ*, Zhou Q*, Li W*. Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals. Cell Stem Cell. 2025;32(3):361-374.

6.Wang J^#*, Zhang Y^#, Gao J^#, Feng G, Liu C, Li X, Li P, Liu Z, Lu F, Wang L*, Li W*, Zhou Q*, Liu Y*. Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos. Nat Struct Mol Biol. 2024;31(9):1341-1354.

7.Guo R^#, Sun X^#, Wang F^#, Han D^#, Yang Q, Gao H, Li Z, Shao Z, Shi J, Yang R, Huo X, Yan J, Li G, Xiao Q, Liu Y, Zhang S, Liu X, Zhou Y, Wang L*, Hu C*, Xu C*. Engineered IscB-ωRNA system with improved base editing efficiency for disease correction via single AAV delivery in mice. Cell Reports. 2024;43(11):114973

8.Huang C^#, Jiang H^#, Dong J^#, Jiang L, Li J, Xu J, Cui T, Wang L, Li X, Feng G, Zhang Y, Li T*, Li W*, Zhou Q*. Functional mouse hepatocytes derived from interspecies chimeric livers effectively mitigate chronic liver fibrosis. Stem Cell Reports. 2024;19(6):877-889.

9.Ren J^#, Hai T^#, Chen Y^#, Sun K, Han Z, Wang J, Li C, Wang Q, Wang L, Zhu H, Yu D*, Li W*, Zhao S*. Improve meat production and virus resistance by simultaneously editing multiple genes in livestock using Cas12iMax. Sci China Life Sci. 2024;67(3):555-564.

10.Chen X^#, Lu Y^#, Wang L, Ma X, Pu J, Lin L, Deng Q, Li Y, Wang W, Jin Y, Hu Z, Zhou Z, Chen G, Jiang L, Wang H, Zhao X, He X, Fu J, Russ HA, Li W, Zhu S*. A fast chemical reprogramming system promotes cell identity transition through a diapause-like state. Nat Cell Biol. 2023;25(8):1146-1156.

11.Sun H^#, Zhang Z^#, Li T^#, Li T, Chen W, Pan T, Fang S, Liu C, Zhang Y, Wang L, Feng G, Li W, Zhou Q*, Zhao Y*. Live-cell imaging reveals redox metabolic reprogramming during zygotic genome activation. J Cell Physiol. 2023;238(9):2039-2049.

12.Jiang L^#, Wang X^#, Wang L^#, Ma S^#, Ding Y, Liu C, Wang S, Shao X, Zhang Y, Li Z, Li W, Feng G*, Zhou Q*. Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution. Protein Cell. 2023;14(12):924-928.

13.Li X^#, Wang J^#, Wang L^#, Gao Y^#, Feng G, Li G, Zou J, Yu M, Li YF, Liu C, Yuan XW, Zhao L, Ouyang H, Zhu JK*, Li W*, Zhou Q*, Zhang K*. Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging. Signal Transduct Target Ther. 2022;7(1):162.

14.Gu Z^#, Guo J^#, Zhai J^#, Feng G^#, Wang X, Gao Z, Li K, Ji S, Wang L, Xu Y, Chen X, Wang Y, Guo S, Yang M, Li L, Han H, Jiang L, Wen Y, Wang L, Hao J, Li W, Wang S*, Wang H*, Gu Q*. A Uterus-Inspired Niche Drives Blastocyst Development to the Early Organogenesis. Adv Sci (Weinh). 2022;9(28):e2202282.

15.Wang LB^#, Li ZK^#, Wang LY^#, Xu K^#, Ji TT^#, Mao YH, Ma SN, Liu T, Tu CF, Zhao Q, Fan XN, Liu C, Wang LY, Shu YJ, Yang N*, Zhou Q*, Li W*. A sustainable mouse karyotype created by programmed chromosome fusion. Science. 2022;377(6609):967-975.

16.Lu X^#, Zhang Y^#, Wang L^#, Wang L^#, Wang H, Xu Q, Xiang Y, Chen C, Kong F, Xia W, Lin Z, Ma S, Liu L, Wang X, Ni H, Li W*, Guo Y*, Xie W*. Evolutionary epigenomic analyses in mammalian early embryos reveal species-specific innovations and conserved principles of imprinting. Science Advances. 2021;7(48):eabi6178.

17.Xie D^#, Tong M^#, Xia B^#, Feng G^#, Wang L^#, Li A, Luo G, Wan H, Zhang Z, Zhang H, Yang YG, Zhou Q, Wang M*, Wang XJ*. Long noncoding RNA lnc-NAP sponges mmu-miR-139-5p to modulate Nanog functions in mouse ESCs and embryos. RNA Biol. 2021;18(6):875-887.

18.Wang F^#, Li A, Meng TG, Wang LY, Wang LJ, Hou Y, Schatten H, Sun QY*, Ou XH*. Regulation of [Ca2+]i oscillations and mitochondrial activity by various calcium transporters in mouse oocytes. Reprod Biol Endocrinol. 2020;18(1):87.

19.Wang LY^#, Li ZK^#, Wang LB^#, Liu C^#, Sun XH^#, Feng GH^#, Wang JQ, Li YF, Qiao LY, Nie H, Jiang LY, Sun H, Xie YL, Ma SN, Wan HF, Lu FL*, Li W*, Zhou Q*. Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer. Cell Stem Cell. 2020;27(2):315-325.

20.Xu Q^#, Xiang Y^#, Wang Q^#, Wang L^#, Brind'Amour J, Bogutz AB, Zhang Y, Zhang B, Yu G, Xia W, Du Z, Huang C, Ma J, Zheng H, Li Y, Liu C, Walker CL, Jonasch E, Lefebvre L, Wu M, Lorincz MC, Li W*, Li L*, Xie W*. SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development. Nat Genet. 2019;51(5):844-856

21.Li Y^#, Wang L^#, Zhang L^#, He Z^#, Feng G, Sun H, Wang J, Li Z, Liu C, Han J, Mao J, Li P, Yuan X, Jiang L, Zhang Y*, Zhou Q*, Li W*. Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I. J Cell Biol. 2019;218(5):1553-1563.

22.Cui T^#, Jiang L^#, Li T^#, Teng F, Feng G, Wang X, He Z, Guo L, Xu K, Mao Y, Wang L, Yuan X, Wang L, Li W*, Zhou Q*. Derivation of Mouse Haploid Trophoblast Stem Cells. Cell Rep. 2019;26(2):407-414.

23.Wang J^#, Wang L^#, Feng G^#, Wang Y^#, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W*, Zhou Q*. Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos. Cell. 2018;175(7):1887-1901.

24.Li ZK^#, Wang LY^#, Wang LB^#, Feng GH^#, Yuan XW^#, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W*, Zhou Q*, Hu BY*. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell. 2018;23(5):665-676

25.Li T^#, Wang L^#, Zhang X^#, Jiang L^#, Li Y, Mao J, Cui T, Li W, Wang L*, Zhou Q*. Generation of rat-mouse chimeras by introducing single cells of rat inner cell masses into mouse blastocysts. J Genet Genomics. 2018 May 18:S1673-8527(18)30082-1.

26.Wang L^#, Teng F^#, Yuan X^#, Liu C^#, Wang J, Li Y, Cui T, Li T, Liu Z*, Zhou Q*. Overexpression of Stella improves the efficiency of nuclear transfer reprogramming. J Genet Genomics. 2017;44(7):363-366.

27.Li Z^#, Wan H^#, Feng G^#, Wang L^#, He Z, Wang Y, Wang XJ, Li W*, Zhou Q*, Hu B*. Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Research. 2016 Jan;26(1):135-8.

28.Wang J^#, Li X^#, Wang L^#, Li J^#, Zhao Y, Bou G, Li Y, Jiao G, Shen X, Wei R, Liu S, Xie B, Lei L, Li W, Zhou Q*, Liu Z*. A novel long intergenic noncoding RNA indispensable for the cleavage of mouse two-cell embryos. EMBO Reports. 2016;17(10):1452-1470.

29.Li T^#, Shuai L^#, Mao J^#, Wang X, Wang M, Zhang X, Wang L, Li Y, Li W, Zhou Q*. Efficient Production of Fluorescent Transgenic Rats using the piggyBac Transposon. Sci Rep. 2016;6:33225.

30.Li X^#, Cui XL^#, Wang JQ^#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W*, Zhou Q*. Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells. Cell. 2016;164(1-2):279-292.

31.Li X^#, Wang JQ^#, Wang LY^#, Wan HF, Li YF, Li TD, Wang YK, Shuai L, Mao YH, Cui XL, Wang L, Liu ZH, Li W, Zhou Q*. Co-participation of paternal and maternal genomes before the blastocyst stage is not required for full-term development of mouse embryos. J Mol Cell Biol. 2015;7(5):486-8.